RHCE Table | NCBGG

Results include both upper and lowercase alleles.

Allele name	Nucleotide	Exon	Amino Acid	Reported as: Linked to:	Ethnicity & Frequency	rs number	Antigen	Antibody	Specificity	Clinical significance	Misc (phenotype)	Reference Links	GenBank ID
RHCE01 or RHCEce RHCEc RHCEe	Reference nucleotides c.307C c.676G	2 5	p.Pro103 p.Ala226			rs676785 rs609320					RH:4 or c RH:5 or e RH:6 or f (ce)	Mouro et al., 1993	Reference Sequence NG_009208.3
RHCE01.01 RHCEce.01	c.48G>C	1	p.Trp16Cys		Asian Black Caucasian	rs586178	frequently weak e	no	auto anti-e possible	none known		Westhoff et al., 2001	DQ266400 Westhoff et al.
RHCE01.02.01 RHCEce.02.01	c.48G>C c.1025C>T	1 7	p.Trp16Cys p.Thr342Ile	RHCEceTI often linked to RHDDIVa	Asian Black Caucasian	rs586178 rs1053374	frequently weak e	c and e	anti-c		partial e partial c	Westhoff et al., 2013	KY369953 Vege et al.
RHCE01.02.02 RHCEce.02.02	c.48G>C c.150C>T c.178C>A c.201A>G c.203A>G c.307C>T c.1025C>T	1 2 7	p.Trp16Cys silent p.Leu60Ile silent p.Asn68Ser p.Pro103Ser p.Thr342Ilep	RHCEceTI (Dex2) reported with RHDDIVa		rs586178 rs200955066 rs181860403 rs1053343 rs1053344 rs676785 rs1053374						Ba et al., 2015	LN680105 Ba et al.
RHCE01.03 RHCEce.03	c.1025C>T	7	p.Thr342Ile	reported with DIIIa	Asian: unknown Black: rare Caucasian: unknown	rs1053374					partial e	Westhoff et al., 2010	MH717897 Vege et al.
RHCE01.04.01 RHCEce.04.01	c.48G>C c.712A>G c.733C>G c.787A>G c.800T>A c.916A>G	1 5 6	p.Trp16Cys p.Met238Val p.Leu245Val p.Arg263Gly p.Met267Lys p.Ile306Val	RHCEceAR often linked to RHDDAR	Asian: none Black: some Caucasian: none	rs586178 rs144163296 rs1053361 rs1132763 rs1132764 rs1132765	frequently weak e	c and e	anti-c anti-e anti-RH19 (-hrS) anti-RH18 (-Hr)	Transfusion reaction reported DAT+ to Mild HDFN	RH:10,─20 (V+^w VS–) RH:─19 (hrS–) partial e	Hemker et al., 1999
RHCE01.04.02 RHCEce.04.02	c.48G>C c.697C>G c.712A>G c.733C>G c.787A>G c.800T>A c.916A>G	1 5 6	p.Trp16Cys p.Gln233Glu p.Met238Val p.Leu245Val p.Arg263Gly p.Met267Lys p.Ile306Val	RHCE*ceAR+697G		rs586178 rs142246017 rs144163296 rs1053361 rs1132763 rs1132764 rs1132765					partial e	Vege et al., 2010 (abstract)	KY369958 Vege et al.
RHCE01.04.03 RHCEce.04.03	c.48G>C c.455C>A c.712A>G c.733C>G c.787A>G c.800T>A c.916A>G	1 3 5 6	p.Trp16Cys p.Thr152Asn p.Met238Val p.Leu245Val p.Arg263Gly p.Met267Lys p.Ile306Val	RHCE*ceAR+455A		rs586178 rs35109888 rs144163296 rs1053361 rs1132763 rs1132764 rs1132765						Vege et al., 2010 (abstract)	KY369957 Vege et al.
RHCE01.05.01 RHCEce.05.01	c.48G>C c.712A>G c.787A>G c.800T>A	1 5	p.Trp16Cys p.Met238Val p.Arg263Gly p.Met267Lys	RHCEceEK often linked to RHDDAR	Asian: unknown Black: some Caucasian: none	rs586178 rs144163296 rs1132763 rs1132764	Frequently weak e	c and e	anti-c anti-e anti-RH19(-hrS) anti-RH18 (-Hr)	Transfusion reaction reported DAT+ to Mild HDFN	RH:─19 (hrS–) partial e partial c	Noizat-Pirenne et al., 2002	AF510065 Noizat-Pirenne et al. KU556685 Flegel et al.
RHCE01.06.01 RHCEce.06.01	c.254C>G	2	p.Ala85Gly	RHCE*ceAG	Asian: unknown Black: some Caucasian: none	rs57992529	weak e	e	anti-e	not known	RH:─59 (CEAG–) RH:─31 (hrB–) partial e	Westhoff et al., 2015	GU810838 Westhoff et al.
RHCE01.06.02 RHCEce.06.02	c.254C>G c.733C>G	2 5	p.Ala85Gly p.Leu245Val	RHCE*ceAG.02 733C>G also in trans		rs57992529 rs1053361					Not tested V and VS not informative	Keller et al., 2014
RHCE01.06.03 RHCEce.06.03	c.254C>G c.733C>G c.941T>C	2 5 7	p.Ala85Gly p.Leu245Val p.Val314Ala	RHCE*ceAG.03		rs57992529 rs1053361 rs79321360					Not tested	Westhoff et al., 2015	KY243887 Vege et al.
RHCE01.06.04 RHCEce.06.04	c.254C>G c.697C>G	2 5	p.Ala85Gly p.Gln233Glu	RHCE*ceAG.04		rs57992529 rs142246017						Westhoff et al., 2015	KY243888 Vege et al.
RHCE01.06.05 RHCEce.06.05	c.254C>G c.307C>T	2	p.Ala85Gly p.Pro103Ser	RHCE*ceAG.05 C+ robust Linked to RHD psuedogene African American		rs57992529 rs676785					RH:2 (partial C+) e+	Westhoff et al., 2015	KY369954 Vege et al.
RHCE01.07.01 RHCEce.07.01	c.48G>C c.667G>T	1 5	p.Trp16Cys p.Val223Phe	RHCEceMO often linked to RHDDAU0	Asian: unknown Black: some Caucasian: some	rs586178 rs147357308	weak e	c and e	anti-c and -e	not known	RH:─19 (hrS–) RH:─31 (hrB–) RH: ─61 (CEVF–) partial e partial c
RHCE01.07.02 RHCEce.07.02	c.667G>T	5	p.Val223Phe	RHCEceMO.02 without 16Cys less often seen than ceMO.01 but also often with RHDDAU0	Asian: unknown Black: rare Caucasian: none	rs147357308					RH:─19 (hrS–) RH:─31 (hrB–) RH: ─61 (CEVF–) partial e partial c	Noizat-Pirenne et al., 2001
RHCE01.08 RHCEce.08	c.48G>C c.712A>G c.818C>T c.1132C>G	1 5 6 8	p.Trp16Cys p.Met238Val p.Ala273Val p.Leu378Val	RHCEceBI often linked to RHDDOL	Asian: unknown Black: some Caucasian: unknown	rs586178 rs144163296 rs147094099 rs138917454	frequently weak e	e	anti-e anti-RH19 (-hrS) anti-RH18 (-Hr)	not known	RH:─19 (hrS–) RH:49 (STEM+) e+/-	Noizat-Pirenne et al., 2002	AF510066 Noizat-Pirenne et al.
RHCE01.09 RHCEce.09	c.48G>C c.712A>G c.818C>T	1 5 6	p.Trp16Cys p.Met238Val p.Ala273Val	RHCE*ceSM	Asian: unknown Black: some Caucasian: unknown	rs586178 rs144163296 rs147094099	not known	not known	not known	not known	RH:─19 (hrS–) Rh:49+^w (STEM+^w) e+/–	Reid et al., 2013	GU474431 Halter Hipsky et al.
RHCE01.10.01 RHCEce.10.01	c.48G>C c.365C>T	1 3	p.Trp16Cys p.Ser122Leu	RHCE*ceSL some alleles have a silent 105C>T change	Asian: none Black: none Caucasian: rare	rs586178 rs201407774	frequently weak e	not known	not known		e+^w weak reactivity with some anti-D monoclonal	Chen et al., 2006
RHCE01.10.02 RHCEce.10.02	c.365C>T	3	p.Ser122Leu	RHCE*ceSL.02	Asian: unknown Black: unknown Caucasian: rare	rs201407774	not known	not known	not known		e+^w (Few monoclonal anti-D weakly cross-react)	Chen et al., 2006	AM072960 Chen et al.
RHCE01.11 RHCEce.11	c.461G>C	3	p.Arg154Thr	RHCE*ceRT	Asian: rare Black: unknown Caucasian: rare	rs747471048	e+^w	not known	not known		e+^w (Some monoclonal anti-D weakly cross-react )	Wager et al., 2003	AM072961 Wagner et al.
RHCE01.12 RHCEce.12	c.48G>C c.538G>C	1 4	p.Trp16Cys p.Gly180Arg	RHCE*ceRA	Asian: rare Black: unknown Caucasian: unknown	rs586178 not found	e weak	not known	not known	not known	e+^w	Noizat-Pirenne et al., 2006
RHCE01.13 RHCEce.13	c.685_687delAGA	5	p.Arg229del	RHCE*ceBP	Asian: rare Black: unknown Caucasian: unknown	not found	very weak e	not known	not known	not known	e+^w RH:58 (CELO+^w)	Chen et al., 2004
RHCE01.14 RHCEce.14	c.662C>G	5	p.Pro221Arg	RHCE*ceBE	Asian: rare Black: unknown Caucasian: unknown	rs141398055	weak c weak e	not known	not known	not known	e+^w, c+^w RH:36 (Be(a+))	Doscher et al., 2009 Hue-Roye et al., 2010	AM295500 Doescher et al.
RHCE01.15 RHCEce.15	c.286G>A	2	p.Gly96Ser	RHCE*ceLOCR	Asian: unknown Black: unknown Caucasian: rare	rs144348222	weak c	not known	not known	not known	c+^w, e+^w RH:55 (LOCR+) RH:-26	Faas et al., 1997 Coghlan et al., 2006
RHCE01.16 RHCEce.16	c.48G>C c.1170C>T c.1193T>A	1 9	p.Trp16Cys silent p.Val398Glu	with pseudogene		rs586178 rs630931 rs630612					e+	Lavoie et al., 2016	KU234778 Lavoie et al.
RHCE01.20.01 RHCEce.20.01 RHCE*ceVS.01	c.733C>G	5	p.Leu245Val	Often linked to conventional RHD	Asian: none Black: common Caucasian: none	rs1053361			anti-e (auto)??	Numerous patients have received e+ blood without adverse effects	partial e partial c RH:10,20 (V+VS+) RH:31 weak to neg (hrB+^vw/–)	Steers et al., 1996 Huang et al., 1997 Faas et al., 1997
RHCE01.20.02 RHCEce.20.02 RHCE*ceVS.02	c.48G>C c.733C>G	1 5	p.Trp16Cys p.Leu245Val	Often linked to RHD*DIIIa or to weak partial D 4.0	Asian: none Black: common Caucasian: none	rs586178 rs1053361			anti-e (auto)??	Numerous patients have received e+ blood without adverse effects	partial e partial c RH:10,20 (V+VS+) RH:─31 (hrB–)	Faas et al., 1997
RHCE01.20.03 RHCEce.20.03 RHCE*ceVS.03	c.48G>C c.733C>G c.1006G>T	1 5 7	p.Trp16Cys p.Leu245Val p.Gly336Cys	RHCEceS, often linked to RHDDIIIa or to hybrid RHDIII-CE-D as part of r’S type 1 or RHD-CE-D as part of type 2 haplotype	Asian: none Black: common Caucasian: none	rs586178 rs1053361 rs116261244		e and c	anti-e or anti-c	not known when linked with hybrid D-CE-D, the C antigen is partial	partial e partial c RH:─10,20 (V─VS+) RH:─31 (hrB–)	Daniels et al., 1998
RHCE01.20.04.01 RHCEce.20.04.01 RHCE*ceVS.04.01	c.48G>C c.733C>G c.1025C>T	1 5 7	p.Trp16Cys p.Leu245Val p.Thr342Ile	ceTI type 2	Asian: none Black: some Caucasian: none	rs586178 rs1053361 rs1053374		not known	not known	not known	partial e RH:10,20 (V+VS+) Probable RH:─31 (hrB–)	Westhoff et al., 2010	KY652757 Vege et al.
RHCE01.20.04.02 RHCEce.20.04.02 RHCE*ceVS.04.02	c.48G>C c.105C>T c.733C>G c.744C>T c.1025C>T	1 5 7	p.Trp16Cys silent p.Leu245Val silent p.Thr342Ile	RHCE*ceTI type 2 as above but noting the silent changes		rs586178 rs142971926 rs1053361 rs149352457 rs1053374
RHCE01.20.05 RHCEce.20.05 RHCE*ceVS.05	c.733C>G c.1006G>T	5 7	p.Leu245Val p.Gly336Cys		Asian: none Black: rare Caucasian: none	rs1053361 rs116261244		not known	not known	not known	partial e RH:─10,20 (V–VS+) RH:─31	Daniels et al., 1998
RHCE01.20.06 RHCEce.20.06 RHCE*ceVS.06	c.48G>C c.697C>G c.733C>G	1 5	p.Trp16Cys p.Gln233Glu p.Leu245Val	RHCE*ceCF	Asian: none Black: some Caucasian: none	rs586178 rs142246017 rs1053361	e +/-	c and e	anti-c anti-e	Anti-CELO DAT+, no HDFN RH:20 (VS+) RH:43 (Crawford+) RH:58 (CELO)	partial c partial e RH:43 (Crawford+) RH:20 (VS+) RH:-19,-31 RH:─58 (CELO–) moderate to strongly reactive with some monoclonal anti-D	Flegel et al., 2006 Hipsky et al., 2011	DQ178642 Westhoff et al.
RHCE01.20.07 RHCEce.20.07 RHCE*ceVS.07	c.340C>T c.733C>G	3 5	p.Arg114Trp p.Leu245Val	RHCE*ceJAL	Asian: none Black: some Caucasian: none	rs148487630 rs1053361	e +/- c +/-	c and e	anti-e anti-c	anti-c possibly involved in transfusion reaction	partial e partial c RH:48,(JAL+) RH:─57 (CEST–) RH:20(V/VS+^w) RH:19(hrS+^w/-) RH:31(hrB+^w/-)	Noizat-Pirenne et al., 2002 Hustinx et al., 2009 Westhoff et al., 2009	AF510067 Noizat-Pirenne et al.
RHCE01.20.08 RHCEce.20.08 RHCE*ceVS.08	c.48G>C c.733C>G c.748G>A	1 5	p.Trp16Cys p.Leu245Val p.Val250Met		Asian: none Black: rare Caucasian: none	rs586178 rs1053361 not found	weak e	not known	not known	not known	e+^w RH:10,20 (V+VS+) Probable RH:─31 (hrB−)	Noizat-Pirenne et al., 2002	AF510068 Noizat-Pirenne et al.
RHCE01.20.09 RHCEce.20.09 RHCE*ceVS.09	c.48G>C c.733C>G c.941T>C	1 5 7	p.Trp16Cys p.Leu245Val p.Val314Ala		Asian: none Black: rare Caucasian: none	rs586178 rs1053361 rs79321360	weak e	e	anti-e	not known	e+^w RH:-10,20 (V–VS+) RH:31 (hrB+^w)	Hue-Roye et al., 2010 (allele reported with 1006G>T)	KX279465 Vrignaud et al.
RHCE01.20.10 RHCEce.20.10 RHCE*ceVS.10	c.48G>C c.712A>G c.733C>G	1 5	p.Trp16Cys p.Met238Val p.Leu245Val			rs586178 rs144163296 rs1053361					probable partial e and partial c	Vege et al., 2010 (abstract)	KY369955 Vege et al.
RHCE01.21.01 RHCEce.21.01	c.341G>A	3	p.Arg114Gln		Asian: one Black: unknown Caucasian: one	not found	weak e	not known	not known	not known	e+^w RH:48 (JAL+)	Hustinx et al., 2009	AJ548432 Wagner et al.
RHCE01.21.02 RHCEce.21.02	c.48G>C c.187G>C c.341G>A	1 2 3	p.Trp16Cys p.Gly63Arg p.Arg114Gln			rs586178 not found not found					e+^w RH:48 (JAL+)	Doescher et al., 2009	AM295498 Doescher et al.
RHCE01.22 RHCEce.22	c.667G>T c.697C>G c.712A>G c.733C>G c.744T>C c.787A>G c.800T>A	5	p.Val223Phe p.Gln233Glu p.Met238Val p.Leu245Val silent p.Arg263Gly p.Met267Lys	DHAR RHCE*ceHAR	Asian: none Black: none Caucasian: some	rs147357308 rs142246017 rs144163296 rs1053361 rs149352457 rs1132763 rs1132764	weak e	not known	not known	not known	e+^w strongly D+ with some monoclonal anti-D RH:33(DHAR+) RH:50 (FPPT+)	Beckers et al., 1996
RHCE01.23 RHCEce.23	c.649T>C	5	p.Trp217Arg		Asian: unknown Black: unknown Caucasian: rare	not found					e+^w	Bugert et al., 2009	FJ486162 Bugert et al.
RHCE01.24 RHCEce.24	c.512A>G	4	p.His171Arg		Asian: unknown Black: unknown Caucasian: rare	rs781037009	weak e				e+^w	Doscher et al.,2009	AM182448 Doescher et al.
RHCE01.25 RHCEce.25	c.730G>A	5	p.Ala244Thr		Asian: unknown Black: unknown Caucasian: rare	not found	weak e				e+^w	Doscher et al., 2009	AM260938 Doescher et al.
RHCE01.26 RHCEce.26	c.872C>T	6	p.Pro291Leu		Asian: unknown Black: unknown Caucasian: rare	rs374399829	weak e				e+^w	Doscher et al., 2009	AM183927 Doescher et al.
RHCE01.27 RHCEce.27	c.1154G>C	9	p.Gly385Ala		Asian: unknown Black: unknown Caucasian: rare	not found	weak e				e+^w	Doscher et al., 2009	AM295499 Doescher et al.
RHCE01.28 RHCEce.28	c.1254A>C	10	p.Ter418Tyr		Asian: unknown Black: unknown Caucasian: rare	not found	weak c				c+^w	Doscher et al., 2009	AM295503 Doescher et al.
RHCE01.29 RHCEce.29	RHD exons 4-9	4-9		RHCE*ceBOL haplotype(Dc– Bol)	Asian: unknown Black: unknown Caucasian: one		Cc+ Ee				c+e-	Cherif-Zahar et al., 1994
RHCE01.30 RHCEce30	c.526G>A	4	p.Ala176Thr		Asian: unknown Black: rare Caucasian: unknown	rs753965768	weak e		not known	not known	e+^w	Pham et al., 2011
RHCE01.31 RHCEce31	c.695T>C	5	p.Ile232Thr		Asian: unknown Black: rare Caucasian: unknown	not found	weak e					Pham et al., 2011
RHCE01.32 RHCEce32	c.827C>A	6	p.Ala276Gln		Asian: unknown Black: rare Caucasian: unknown	not found						Pham et al., 2011
RHCE01.33 RHCEce33	c.506T>C	4	p.Leu169Pro			not found					partial e e+^w/− RH:-31 (hrB–)	Vege et al., 2010 (abstract)	KX714949 Vege, S et al.
RHCE01.34 RHCEce34	RHD exons 4-7	4-7		Haplotype Dc− Made antibody to high		NA					partial c+e-	Lomas-Francis et al., 2014 (abstract)	KY652756 Vege et al.
RHCE01.35 RHCEce35	c.202A>G	2	p.Asn68Asp	(ce in trans)		rs772058645					c+ e+	Goldman et al., 2016	KP136911 Hyland et al.
RHCE01.36 RHCEce36	c.307C>T	2	p.Pro103Ser	(C in trans)		rs676785					c–	Goldman et al., 2016	KP136912 Cemborain et al.
RHCE01.37 RHCEce37	c.697C>G c.712A>G c.733C>G c.744T>C	5	p.Gln233Glu p.Met238Val p.Leu245Val p.Ser248Ser	Reported as weakly reactive with anti-D in absence of RHD		rs142246017 rs144163296 rs1053361 rs149352457					c+ e+	Goldman et al., 2016	KP136915 Garcia et al.
RHCE01.38 RHCEce38	c.1-10C>T	5’UTR	promoter region			rs369957834					weakened e	Doescher et al., 2009	FM866412 Doescher et al.
RHCE01.39 RHCEce39	c.308C>T	2	p.Pro103Leu			rs747882675					C+^w c-	Stegmann et al., 2016	KU319432 Ji et al.
RHCE01.40 RHCEce40	c.340C>T	3	p.Arg114Trp			rs148487630					c+^w	Vrignaud et al., 2014 (abstract)
											Nulls
RHCE01N.01 RHCEceN.01	c.80_84delTCTTC	1	p.Tyr29Phefs*5			not found	ce		first found in a sample with anti-Rh17 and anti-Rh29	no to severe HDFN	c–e–	Kato-Yamazaki et al., 2000
RHCE01N.02 RHCEceN.02	c.963delG	7	p.Iso322Phefs*37			not found	ce		anti-Rh17, anti-Rh29		c–e–	Rosa et al., 2005
RHCE01N.03 RHCEceN.03	c.634+1G>T	Intron 4	Splice site			not found	ce		anti-Rh17, anti-Rh29		c–e–	Cherif-Zahar et al., 1998
RHCE01N.04 RHCEceN.04	c.676delG	5	p.Ala226Leufs*3			rs609320					c–e–		KY652755 Vege et al.
RHCE01N.05 RHCEceN.05	c.335+3A>T	Intron 2	Splice site			not found					c–e–		KX714951 Vege et al.
RHCE01N.06 RHCEceN.06	c.679_683delCTGCT	5	p.Leu227Glufs*89			not found					c–e–	Pham et al., Transfusion 2013
RHCE01N.07 RHCEceN.07	c.1074-2A>G	Intron 7	Splice site			not found					c–e–	Pham et al., Transfusion 2013
RHCE01N.08 RHCEceN.08	c.801+1G>A	5	splice site			not found					c–e–	Kulkarni et al., 2017	KY229720 Fichou et al.
RHCE01N.09 RHCEceN.09	c.1044_1050dupGCTTCAT	7	p.Thr351Alafs*52			not found					c–e–	Sylvie et al., 2015
RHCE01N.10 RHCEceN.10	c.807T>A	6	p.Tyr269Ter			rs780267740					c–e–	Thonier et al., 2017 (abstract)
RHCE02 or RHCECe RHCEC RHCEe	Reference nucleotides c.48G>C c.150C>T c.178C>A c.201A>G c.203A>G c.307C>T c.676G	1 2 5	p.Trp16Cys silent p.Leu60Ile silent p.Asn68Ser p.Pro103Ser p.Ala226								Ce RH:2 or C RH:5 or e RH:7 or rhi(Ce)	Mouro et al., 1993	BC075081 Strausberg et al.
RHCE02.01 RHCECe.01	c.340C>T	3	p.Arg114Trp	RHCECeMA RHCECeJAL	Asian: unknown Black: unknown Caucasian: rare	rs148487630	weak C+ weak e+		not known	not known	C+^w/- e+^w RH:48(JAL+)	Noizat-Pirenne et al., 2002	AJ548431 Wagner et al. AM183925 Doescher et al.
RHCE02.02 RHCECe.02	c.667G>T c.697C>G c.712A>G	5	p.Val223Phe p.Gln233Glu p.Met238Val	RHCE*CeFV	Asian: unknown Black: unknown Caucasian: rare	rs147357308 rs142246017 rs144163296			not known	not known	C+e+	Bugert et al., 2009	AJ867777 Doescher et al.
RHCE02.03 RHCECe.03	c.365C>T	3	p.Ser122Leu	RHCE*CeJAHK	Asian: unknown Black: unknown Caucasian: rare	rs201407774	weak C+, weak e+		not known	not known	C+^w e+^w RH:53(JAHK+) rG	Scharberg et al., 2005	AM999773 Doescher et al.. (called CeSI in GenBank)
RHCE02.04 RHCECe.04	c.667G>T c.697C>G c.712A>G c.733C>G c.744T>C c.787A>G c.800T>A	5	p.Val223Phe p.Gln233Glu p.Mer238Val p.Leu245Val silent p.Arg263Gly p.Met267Lys	RHCE*CeVA	Asian: unknown Black: unknown Caucasian: rare	rs147357308 rs142246017 rs144163296 rs1053361 rs149352457 rs1132763 rs1132764	C weak+/-		not known	not known	partial C+	Noizat-Pirenne et al., 2002
RHCE02.04.01 RHCECe.04.01	c.667G>T c.697C>G c.712A>G c.733C>G c.744T>C c.787A>G	5	p.Val223Phe p.Gln233Glu p.Mer238Val p.Leu245Val silent p.Arg263Gly			rs147357308 rs142246017 rs144163296 rs1053361 rs149352457 rs1132763					C+^w e+^w	Doescher et al., 2009	AM999774 Doescher et al.
RHCE02.05 RHCECe.05	c.501G>A	4	p.Met167Ile	RHCE*CePARG		not found					RH:60 (PARG+)	Scharberg et al., 2017
RHCE02.08.01 RHCECe.08.01	c.122A>G	1	p.Gln41Arg	RHCE*CeCW	Asian: unknown Black: unknown Caucasian: some	rs138268848		anti-51 like/MAR like	Anti-C, Anti-rhi	not known	partial C+ RH:8 (CW+) RH:–51 (MAR–)	Mouro et al., 1995
RHCE02.08.02 RHCECe.08.02	c.122A>G RHD exon 6-10	1 6-10	p.Gln41Arg	RHCE*CeNR	Asian: unknown Black: one Caucasian: unknown	rs138268848					RH:8 (CW+) RH:–56 (CENR–)	Westhoff et al., 2004
RHCE02.09 RHCECe.09	c.106G>A	1	p.Ala36Thr	RHCE*CeCX	Asian: unknown Black: unknown Caucasian: uncommon	rs145034271		anti-51 like/MAR like	Anti-C, Anti-rhi	not known	partial C+ RH:9 (CX+) RH:–51 (MAR–)	Mouro et al., 1995
RHCE02.10.01 RHCECe.10.01	c.505C>A c.509G>T c.514T>A c.544A>T c.577A>G c.594T>A c.602G>C	4	p.Leu169Met p.Arg170Met p.Phe172Ile p.Thr182Ser p.Lys193Glu p.Asn198Lys p.Arg201Thr	RHCE*CeRN	Asian: none Black: some Caucasian: none	rs1132761 rs1132762 rs1053349 rs1053350 not found rs1053354 rs141398055	weak C+, weak e+	C	Anti-C, Anti-Rh46	Anti-Rh46 and anti-C are clinically significant. No to severe HDFN	C+^w/⁻partial, e+^w RH:32 (RN) RH:54 (DAK+) RH:–46 (Sec–)	Rouillac et al., 1996
RHCE02.10.02 RHCECe.10.02	c.455C>A c.505C>A c.509G>T c.514T>A c.544A>T c.577A>G c.594T>A c.602G>C	3 4	p.Thr152Asn p.Leu169Met p.Arg170Met p.Phe172Ile p.Thr182Ser p.Lys193Glu p.Asn198Lys p.Arg201Thr	RHCE*CeRN.02 exists?	Asian: none Black: some Caucasian: none	rs35109888 rs1132761 rs1132762 rs1053349 rs1053350 not found rs1053354 rs141398055	weak C+, weak e+	C	Anti-C, Anti-Rh46	Anti-Rh46 and anti-C are clinically significant. No to severe HDFN	C+^w/− partial, e+^w RH:32 (RN) RH:54 (DAK+) RH:–46 (Sec–)	Rouillac et al., 1996
RHCE02.11 RHCECe.11	c.286G>A	2	p.Gly96Ser		Asian: unknown Black: unknown Caucasian: rare	rs144348222	weak C				C+^w	Doscher et al., 2009	AM295502 Doescher et al.
RHCE02.12 RHCECe.12	c.344T>G	3	p.Leu115Arg		Asian: unknown Black: unknown Caucasian: rare	not found	weak C				C+^w	Doscher et al., 2009	AJ867774 Doescher et al.
RHCE02.13 RHCECe.13	c.364T>C	3	p.Ser122Pro		Asian: unknown Black: unknown Caucasian: rare	not found					e+^w	Bugert et al., 2009	FJ486157 Bugert et al.
RHCE02.14 RHCECe.14	c.497A>T	4	p.His166Leu		Asian: unknown Black: unknown Caucasian: rare	not found	weak C				C+^w	Bugert et al., 2009	FJ486159 Bugert et al.
RHCE02.15 RHCECe.15	c.689G>C	5	p.Ser230Thr		Asian: unknown Black: unknown Caucasian: rare	not found	weak e				e+^w	Doscher et al., 2009	AM182449 Doescher et al.
RHCE02.16 RHCECe.16	c.728A>G	5	p.Tyr243Cys		Asian: unknown Black: unknown Caucasian: rare	rs555090649	weak C, weak e				C+^w e+^w	Doscher et al., 2009	FM165579 Doescher et al.
RHCE02.17 RHCECe.17	c.800T>A	5	p.Met267Lys		Asian: unknown Black: unknown Caucasian: rare	rs1132764					e+^w	Bugert et al., 2009	FJ486164 Bugert et al.
RHCE02.18 RHCECe.18	c.890T>C	6	p.Leu297Pro		Asian: unknown Black: unknown Caucasian:rare	rs763017817	weak C weak e+				C+^w e+^w	Doscher et al., 2009	AM295501 Doescher et al.
RHCE02.19 RHCECe.19	c.464T>G c.1118C>T	3 8	p.Met155Arg p.Ala373Val		Asian: unknown Black: unknown Caucasian: rare	not found not found	weak e				e+^w	Doscher et al., 2009	AM295506 Doescher et al.
RHCE02.20 RHCECe.20	c.79_81delCTC	1	p.Leu27del		Asian: unknown Black: unknown Caucasian: rare	not found	weak C				C+^w e+^w	Doscher et al., 2009	AM410878 Doescher et al.
RHCE02.21 RHCECe.21	c.527C>T	4	p.Ala176Val		Asian: unknown Black: unknown Caucasian: rare	not found	weak C				C+^w	Pham et al., 2011	KM975479 Vrignaud et al.
RHCE02.22 RHCECe.22	c.667G>T	5	p.Val223Phe		Asian: unknown Black: unknown Caucasian: rare	rs147357308	weak C weak e				Partial e+^w C+^w	Pham et al., 2011
RHCE02.23 RHCECe.23	c.941T>C	7	p.Val314Ala		Asian: unknown Black: unknown Caucasian: rare	rs79321360	weak C				C+^w	Pham et al., 2011
RHCE02.24 RHCECe.24	c.1007G>A	7	p.Gly336Asp		Asian: unknown Black: unknown Caucasian: rare	rs760319839	weak C weak e				C+^w e+^w	Pham et al., 2011
RHCE02.25 RHCECe.25	c.1007G>T	7	p.Gly336Val		Asian: unknown Black: unknown Caucasian: rare	rs760319839	weak C				C+^w	Pham et al., 2011
RHCE02.26 RHCECe.26	c.460A>G	3	p.Arg154Gly			rs755299894					C+^w e+^w	Hellberg et al., 2016	KU744002 Hellber et al.
RHCE02.27 RHCECe.27	c.375C>G	3	p.Ile125Met			rs143715642					C+^w e+^w	Vrignaud et al., 2014 (abstract)	KM078027 Vrignaud et al.
RHCE02.28 RHCECe.28	c.919G>A	6	p.Gly307Arg	Surprisingly CX+ in absence of c.106A Made antibody to high in Rh		rs200950594					C+ e+ RH:9	Vege et al., 2010 (abstract)	KY190222 Vege et al.
RHCE02.29 RHCECe.29	c.674C>G	5	p.Ser225Cys	E: 0-4+ depending on reagent, in absence of c.676C		rs200087488					C+ e+ E+/–	Vege et al., 2012 (abstract)	KY190223 Vege et al.
RHCE02.30 RHCECe.30	c.733C>G	5	p.Leu245Val			rs1053361					C+ e+ V+VS+	Goldman et al., 2016	KP136918 Kalvelage et al.
RHCE02.31 RHCECe.31	c.487-5T>G	Intron 3	Splice site			rs776819527					C+^w e+^w	Doescher et al., 2009	FM866415 Doescher et al.
RHCE02.32 RHCECe.32	c.1228-2A>G	Intron 9	Splice site			not found					C+^w	Doescher et al., 2009	FM866417 Doescher et al.
RHCE02.33 RHCECe.33	c.98A>C	1	p.His33Pro			not found					C+^w	Vrignaud et al., 2014 (abstract)
RHCE02.34 RHCECe.34	c.473G>A	3	p.Ser158Asn			rs758173067					C+^w e+^w	Vrignaud et al., 2014 (abstract)
RHCE02.35 RHCECe.35	c.491A>G	4	p.Asp164Gly			rs548044758					C+^w	Vrignaud et al., 2014 (abstract)
RHCE02.36 RHCECe.36	c.494A>C	4	p.Tyr165Ser			rs746303049					C+^w	Vrignaud et al., 2014 (abstract)
											Nulls
RHCE02N.01 RHCECeN.01	c.966_968delinsC	7	p.His323Profs*77			not found	Ce		Anti-Rh17?		C–e–	Cherif-Zahar et al., 1998 Huang et al., 1998
RHCE02N.02 RHCECeN.02	c.659G>A	5	p.Trp220Ter			not found					C–e–		KX714950 Vege et al.
RHCE02N.03 RHCECeN.03	c.486+1G>A	Intron 3	Splice site			rs753832633					C–e–		KP334130 Vege et al.
RHCE02N.04 RHCECeN.04	c.93_94insT	1	p.Thr32Tyrfs*3			not found					C–e–	Ochoa-Garay et al., 2013
RHCE02N.05 RHCECeN.05	c.377C>G	3	p.Ser126Ter			not found					C–e–	Goldman et al., 2016	KP136914 Goldman et al.
RHCE02N.06 RHCECeN.06	c.148+5G>A	Intron 1	Splice site			not found					C–e–	Ochoa-Garay et al., 2013
RHCE02N.07 RHCECeN.07	RHD exons 3-8	3-8				NA					C–e–	Silvy et al., 2012 Ochoa-Garay et al., 2013
RHCE02N.08 RHCECeN.08	RHD exons 3-9	3-9				NA					C–e–	Ochoa-Garay et al., 2013
RHCE02N.09 RHCECeN.09	c.938delC	6	p.Pro313Argfs*46			not found					C–e–	Vrignaud et al., 2014 (abstract)
RHCE03 or RHCEcE RHCEc RHCEE	Reference nucleotides c.307C c.676G>C	2 5	p.Pro103 p.Ala226Pro								cE RH:4 or c RH:3 or E RH:27 (cE)	Mouro et al., 1993
RHCE03.01 RHCEcE.01	c.500T>A	4	p.Met167Lys	RHCE*cEEW	Asian: rare Black: unknown Caucasian: rare	rs140421430	E weak+/-	E	Anti-E		partial E RH:11 (EW +) E type I	Noizat-Pirenne et al., 1998 Strobel et al., 2004
RHCE03.02 RHCEcE.02	RHD exons 1-3	1-3		RHCE*cEKK	Asian: rare Black: unknown Caucasian: rare	NA	E weak+/- c weak+/-				partial E c+^w/− E+^w/- E type II	Noizat-Pirenne et al., 1998 Kashiwase et al., 2001	AB049753 Kashiwase et al.
RHCE03.03 RHCEcE.03	c.697C>G c.712A>G	5	p.Gln233Glu p.Met238Val	RHCE*cEFM	Asian: rare Black: unknown Caucasian: rare	rs142246017 rs144163296	E weak +/-		no		partial E E+^w or E+/- E type III	Kashiwase et al., 2001 Noizat-Pirenne et al., 1998	AB018644 Kashiwase et al.
RHCE03.03.02 RHCEcE.03.02	c.697C>G c.712A>G c.733C>G c.744T>C	5	p.Gln233Glu p.Met238Val p.Leu245Val silent			rs142246017 rs144163296 rs1053361 rs149352457					partial E E+/-	Vege et al., 2010 (abstract)	KY369956 Vege et al.
RHCE03.04 RHCEcE.04	c.602G>C	4	p.Arg201Thr	RHCE*cEIV	Asian: unknown Black: unknown Caucasian: rare	rs141398055	E weak +/-		no		partial E E+^w or E+/- c+^w E type IV	Noizat-Pirenne et al., 1999 (abstract)	FJ486161 Bugert et al.
RHCE03.05 RHCEcE.05	c.461G>C	3	p.Arg154Thr	RHCE*cEKH	Asian: rare Black: unknown Caucasian: unknown	rs747471048	E weak +/- c weak +/-	E	Anti-E		partial E E+^w or E+/- c+^w E type V	Kashiwase et al., 2001	AB018645 Kashiwase et al.
RHCE03.06 RHCEcE.06	c.28C>T	1	p.Arg10Trp		Asian: unknown Black: unknown Caucasian: rare	rs749601047	weak c weak E				E+^w c+^w	Bugert et al., 2009	FJ486155 Bugert et al.
RHCE03.07 RHCEcE.07	c.344T>C	3	p.Leu115Pro		Asian: unknown Black: unknown Caucasian: rare	not found	weak E+				E+^w	Doscher et al., 2009 Bugert et al., 2009	FJ486156 Bugert et al.
RHCE03.08 RHCEcE.08	c.356G>A	3	p.Ser119Asn			rs777819701	weak E+				E+^w	Doscher et al., 2009	AM295505 Doescher et al.
RHCE03.09 RHCEcE.09	c.374T>A	3	p.Ile125Asn		Asian: unknown Black: unknown Caucasian: rare	not found	weak c weak E				E+^w c+^w	Bugert et al., 2009	FJ486158 Bugert et al.
RHCE03.10 RHCEcE.10	c.506T>A	4	p.Leu169Gln		Asian: unknown Black: unknown Caucasian: rare	not found	weak E				E+^w	Bugert et al., 2009	FJ486160 Bugert et al.
RHCE03.11 RHCEcE.11	c.908T>A	6	p.Leu303Gln		Asian: unknown Black: unknown Caucasian: rare	not found	weak c weak E				E+^w c+^w	Bugert et al., 2009	FJ486165 Bugert et al.
RHCE03.12 RHCEcE.12	c.464T>G c.477T>G	3	p.Met155Arg p.Asn159Lys		Asian: unknown Black: unknown Caucasian: rare	not found not found	weak E+				E+^w	Doscher et al., 2009	AM183926 Doescher et al.
RHCE03.13 RHCEcE.13	c.728A>G	5	p.Tyr243Cys		Asian: unknown Black: unknown Caucasian: rare	rs555090649	weak E weak c				E+^w c+^w	Pham et al., 2011
RHCE03.14 RHCEcE.14	c.734T>C	5	p.Leu245Pro		Asian: unknown Black: unknown Caucasian: rare	not found	E very weak+/- weak c				c+^w E^vw−/+	Silvy et al., 2013
RHCE03.15.01 RHCEcE.15.01	c.380C>T c.383G>A	3	p.Ala127Val p.Gly128Asp	RHCE*cE BA		rs1053346 rs1053347	weak E				E+^w	Pham et al., 2011
RHCE03.15.02 RHCEcE.15.02	c.361A>T c.380C>T c.383G>A	3	p.Met121Leu p.Ala127Val p.Gly128Asp	RHCE*cE JU	Asian: unknown Black: unknown Caucasian: rare	rs1053345 rs1053346 rs1053347	weak E				E+^w	Pham et al., 2011
RHCE03.16 RHCEcE.16	c.94A>G	1	p.Thr32Ala	RHCE*cE TA anti-c clone 951 non-reactive		rs760999674					c+^w	Yassai et al., 2015	KP271157 Yassai et al.
RHCE03.17 RHCEcE.17	c.520G>A	4	p.Val174Met			rs146306079					partial E	Vege et al., 2010 (abstract)	KY190221 Vege et al.
RHCE03.18 RHCEcE.18	c.48G>C	1	p.Trp16Cys			rs586178					c+ E+	Vege et al., 2010 (abstract)	KY228976 Vege et al.
RHCE03.19 RHCEcE.19	c.84C>A	1	p.Phe28Leu	c: 0 to 3+ E: 0 to 1+ depending on reagent		not found					c+^w/- E+^w/−	Goldman et al., 2016	KP136913 Goldman et al. LN554880 Henny et al.
RHCE03.20 RHCEcE.20	c.149-1G>A	Intron 1	Splice site			not found					c+^w E+^w+/-	Doescher et al., 2009	FM866414 Doescher et al.
RHCE03.21 RHCEcE.21	c.527C>T	4	p.Ala176Val			not found					E+^w	Vrignaud et al., 2014 (abstract)
RHCE03.22 RHCEcE.22	c.208C>T	2	p.Arg70Trp			not found					E+^w	Vrignaud et al., 2014 (abstract)
RHCE03.23 RHCEcE.23	c.774T>A c.916A>G	5	Silent p.Ile306Val			not found rs1132765					E+^w	Vrignaud et al., 2014 (abstract)
RHCE03.24 RHCEcE.24	c.1130A>T	8	p.Ala377Val			not found					E+^w	Vrignaud et al., 2014 (abstract)
											Nulls
RHCE03N.01 RHCEcEN.01	c.350_358delCCATGAGTG	3	p.Arg120_ Ser122del	RHCE*cEMI	Asian: unknown Black: unknown Caucasian:	not found	cE		Anti-Rh17?		c–E–	Noizat-Pirenne et al., 2001
RHCE03N.02 RHCEcEN.02	c.907delC	6	p.Leu303Ter		Asian: unknown Black: unknown Hispanic: some Caucasian: unknown	rs747976226	cE				c–E–	Westhoff et al., 2011	GU563377 Westhoff et al.
RHCE03N.03 RHCEcEN.03	c.554G>A	4	p.Trp185Ter			not found					c–E–	Paccapelo et al., 2016 (abstract)
RHCE04N.04 RHCEcEN.04	c.486+5G>A	Intron 3	Splice site			not found		made Anti-RH17			c–E–	Pham et al., 2013
RHCE04N.05 RHCEcEN.05	c.221G>A	2	p.Trp74Ter			rs1044945369					c–E–	Ochoa-Garay et al., 2013
RHCECE or RHCE04 RHCEC RHCEE	Reference nucleotides c.48G>C c.150C>T c.178C>A c.201A>G c.203A>G c.307C>T c.676G>C	1 2 5	p.Trp16Cys silent p.Leu60Ile silent p.Asn68Ser p.Pro103Ser p.Ala226Pro								CE RH:2 or C RH:3 or E RH:22 or CE	Mouro et al., 1993
RHCE04.01 RHCECE.01	c.722C>T	5	p.Thr241Ile		Asian: unknown Black: unknown Caucasian: one	rs751751505		Weak C E weak+/-			C+^w E+/–	Bugert et al., 2009	FJ486163 Bugert et al.