Results include both upper and lowercase alleles.
Allele name | Nucleotide | Exon | Amino Acid | Reported as: Linked to: | Ethnicity & Frequency | rs number | Antigen | Antibody | Specificity | Clinical significance | Misc (phenotype) | Reference Links | GenBank ID |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RHCE*01 or | Reference nucleotides |
|
|
|
|
| RH:4 or c |
|
|
|
| Mouro et al., 1993 | Reference Sequence |
RHCE*01.01 | c.48G>C | 1 | p.Trp16Cys |
| Asian | rs586178 | RH:5 (e+ weak) | no | auto anti-e possible | none known |
| Westhoff et al., 2001 | DQ266400 |
RHCE*01.02.01 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceTI often linked to RHD*DIVa | Asian | rs586178 | RH:4 (c+ weak) | c and e | anti-c |
|
| Westhoff et al., 2013 | KY369953 |
RHCE*01.02.02 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceTI (Dex2), reported with RHD*DIVa |
| rs586178 |
|
|
|
|
| Ba et al., 2015 | LN680105 |
RHCE*01.03 | c.1025C>T | 7 | p.Thr342Ile | reported with RHD*DIIIa | Asian: unknown | rs1053374 | RH:5 (e+ partial) |
|
|
|
| Westhoff et al., 2010 | MH717897 |
RHCE*01.04.01 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceAR, often linked to RHD*DAR | Asian: none | rs586178 | RH:4 (c+ partial) | c and e | anti-c anti-e | Transfusion reaction reported DAT+ to Mild HDFN |
| Hemker et al., 1999 | not found |
RHCE*01.04.02 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceAR+697G |
| rs586178 | RH:5 (e+ partial) |
|
|
|
| Vege et al., 2010 (abstract) | KY369958 |
RHCE*01.04.03 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceAR+455A |
| rs586178 |
|
|
|
|
| Vege et al., 2010 (abstract) | KY369957 |
RHCE*01.05.01 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceEK, often linked to RHD*DAR | Asian: unknown | rs586178 | RH:4 (c+ partial) | c and e | anti-c anti-e | Transfusion reaction reported DAT+ to Mild HDFN |
| Noizat-Pirenne et al., 2002 | AF510065 |
RHCE*01.05.02 | c.712A>G | 5 | p.Met238Val | RHCE*ceEK without 48C |
| rs144163296 |
|
|
|
|
| Deleers et al., 2020 | not found |
RHCE*01.06.01 | c.254C>G | 2 | p.Ala85Gly | RHCE*ceAG | Asian: unknown | rs57992529 | RH:5 (e+ weak, partial) | e | anti-e | not known |
| Westhoff et al., 2015 | GU810838 |
RHCE*01.06.02 | c.254C>G | 2 | p.Ala85Gly | RHCE*ceAG.02 |
| rs57992529 |
|
|
|
| Not tested | Keller et al., 2014 | not found |
RHCE*01.06.03 | c.254C>G | 2 | p.Ala85Gly | RHCE*ceAG.03 |
| rs57992529 |
|
|
|
| Not tested | Westhoff et al., 2015 | KY243887 |
RHCE*01.06.04 | c.254C>G | 2 | p.Ala85Gly | RHCE*ceAG.04 |
| rs57992529 |
|
|
|
|
| Westhoff et al., 2015 | KY243888 |
RHCE*01.06.05 | c.254C>G | 2 | p.Ala85Gly | RHCE*ceAG.05 |
| rs57992529 | RH:2 (C+ partial, robust C+ expression) |
|
|
| robust RH:2 (C+) expression | Westhoff et al., 2015 | KY369954 |
RHCE*01.07.01 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceMO, often linked to RHD*DAU0 | Asian: unknown | rs586178 | RH:4 (c+ partial) | c and e | anti-c and -e | not known |
| Noizat-Pirenne et al., 2001Westhoff et al., 2013 | not found |
RHCE*01.07.02 | c.667G>T | 5 | p.Val223Phe | RHCE*ceMO.02 without 16Cys, less often seen than ceMO.01 | Asian: unknown | rs147357308 | RH:4 (c+ partial) |
|
|
|
| Westhoff et al., 2013 | not found |
RHCE*01.08 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceBI, often linked to RHD*DOL | Asian: unknown | rs586178 | RH:5 (e+ partial, weak to neg) | e | anti-e | not known |
| Noizat-Pirenne et al., 2002 | AF510066 |
RHCE*01.09 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceSM | Asian: unknown | rs586178 | RH:5 (e+ positive to negative) | not known | not known | not known |
| Reid et al., 2013 | GU474431 |
RHCE*01.10.01 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceSL | Asian: none | rs586178 | RH:5 (e+ weak) | not known | not known |
| weak reactivity with some anti-D monoclonal | Chen et al., 2006 | not found |
RHCE*01.10.02 | c.365C>T | 3 | p.Ser122Leu | RHCE*ceSL.02 | Asian: unknown | rs201407774 | RH:5 (e+ weak) | not known | not known |
| Few monoclonal anti-D weakly cross-react | Chen et al., 2006 | AM072960 |
RHCE*01.11 | c.461G>C | 3 | p.Arg154Thr | RHCE*ceRT | Asian: rare | rs747471048 | RH:5 (e+ weak) | not known | not known |
| Some monoclonal anti-D weakly cross-react | Wager et al., 2003 | AM072961 |
RHCE*01.12 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceRA | Asian: rare | rs586178 | RH:5 (e+ weak) | not known | not known | not known |
| Noizat-Pirenne et al., 2006 | not found |
RHCE*01.13 | c.687_689delAAG | 5 | p.Arg229del | RHCE*ceBP | Asian: unknown | rs1437180947 | RH:5 (e+ very weak) | not known | not known | not known |
| Chen et al., 2004 | not found |
RHCE*01.14 | c.662C>G | 5 | p.Pro221Arg | RHCE*ceBE | Asian: rare | rs141398055 | RH:4 (c+ weak) | not known | not known | not known |
| Doscher et al., 2009Hue-Roye et al., 2010 | AM295500 |
RHCE*01.15 | c.286G>A | 2 | p.Gly96Ser | RHCE*ceLOCR | Asian: unknown | rs144348222 | RH:4 (c+ weak) | not known | not known | not known |
| Faas et al., 1997Coghlan et al., 2006 | not found |
RHCE*01.16 | c.48G>C | 1 | p.Trp16Cys | with RHD*pseudogene |
| rs586178 | RH:5 (e+ weak) |
|
|
|
| Lavoie et al., 2016 | KU234778 |
RHCE*01.20.01 | c.733C>G | 5 | p.Leu245Val | Often linked to conventional RHD*01 | Asian: none | rs1053361 | RH:4 (c+ partial) |
| anti-e (auto)?? | Numerous patients have received e+ blood without adverse effects |
| Steers et al., 1996Huang et al., 1997Faas et al., 1997 | not found |
RHCE*01.20.02 | c.48G>C | 1 | p.Trp16Cys | Often linked to RHD*DIIIa or to RHD*weak partial D 4.0 | Asian: none | rs586178 | RH:4 (c+ partial) |
| anti-e (auto)?? | Numerous patients have received e+ blood without adverse effects |
| Faas et al., 1997 | not found |
RHCE*01.20.03 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceS, often linked to RHD*DIIIa, to hybrid RHD*DIIIa-CEVS(4-7)-D as part of r’S type 1 or to RHD*D-CEVS(4-7)-D as part of r’S type 2 haplotype | Asian: none | rs586178 | RH:4 (c+ partial) | e and c | anti-e or anti-c | not known |
| Daniels et al., 1998 | not found |
RHCE*01.20.04.01 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceTI type 2 | Asian: none | rs586178 | RH:5 (e+ partial) | not known | not known | not known |
| Westhoff et al., 2010 | KY652757 |
RHCE*01.20.04.02 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceTI type 2 as above but noting the silent changes |
| rs586178 |
|
|
|
|
| not found | |
RHCE*01.20.05 | c.733C>G | 5 | p.Leu245Val |
| Asian: none | rs1053361 | RH:5 (e+ partial) | not known | not known | not known |
| Daniels et al., 1998 | not found |
RHCE*01.20.06 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceCF | Asian: none | rs586178 | RH:4 (c+ partial) | c and e | anti-c anti-e | Anti-CELO DAT+, no HDFN | Moderate to strongly reactive with some monoclonal anti-D | Flegel et al., 2006Hipsky et al., 2011 | DQ178642 |
RHCE*01.20.07 | c.340C>T | 3 | p.Arg114Trp | RHCE*ceJAL | Asian: none | rs148487630 | RH:4 (c+ partial, weak to neg) | c and e | anti-e anti-c | anti-RH4 (c) possibly involved in transfusion reaction |
| Noizat-Pirenne et al., 2002Hustinx et al., 2009Westhoff et al., 2009 | AF510067 |
RHCE*01.20.08 | c.48G>C | 1 | p.Trp16Cys |
| Asian: none | rs586178 | RH:5 (e+ weak) |
|
|
|
| Noizat-Pirenne et al., 2002 | AF510068 |
RHCE*01.20.09 | c.48G>C | 1 | p.Trp16Cys |
| Asian: none | rs586178 | RH:5 (e + weak) | e | anti-e | not known |
| Hue-Roye et al., 2010 (allele reported with 1006G>T) | KX279465 |
RHCE*01.20.10 | c.48G>C | 1 | p.Trp16Cys |
|
| rs586178 | Probable RH:4 (c+ partial) |
|
|
|
| Vege et al., 2010 (abstract) | KY369955 |
RHCE*01.20.11 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceS-DIIIa(2-3)-ce |
| rs586178 |
|
|
|
|
| Aeschlimann et al. 2017 | KY926711 |
RHCE*01.20.12 | c.48G>C | 1 | p.Trp16Cys | RHCE*ceS+462T |
| rs586178 | Some monoclonal anti-D cross-react |
|
|
| Reactive with anti-D (Immucor gammaclone) | Vege et al. 2020 | MW349827 |
RHCE*01.21.01 | c.341G>A | 3 | p.Arg114Gln |
| Asian: one | rs1238030431 | RH:5 (e+ weak) |
|
|
|
| Hustinx et al., 2009 | AJ548432 |
RHCE*01.21.02 | c.48G>C | 1 | p.Trp16Cys |
|
| rs586178 | RH:5 (e+ weak) |
|
|
|
| Doescher et al., 2009 | AM295498 |
RHCE*01.22 | c.667G>T | 5 | p.Val223Phe | DHAR, RHCE*ceHAR | Asian: none | rs147357308 | RH:5 (e+ weak) |
|
|
| strongly D+ with some monoclonal anti-D | Beckers et al., 1996 | not found |
RHCE*01.23 | c.649T>C | 5 | p.Trp217Arg |
| Asian: unknown | not found | RH:5 (e+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486162 |
RHCE*01.24 | c.512A>G | 4 | p.His171Arg |
| Asian: unknown | rs781037009 | RH:5 (e+ weak) |
|
|
|
| Doscher et al.,2009 | AM182448 |
RHCE*01.25 | c.730G>A | 5 | p.Ala244Thr |
| Asian: unknown | rs1307519228 | RH:5 (e+ weak) |
|
|
|
| Doscher et al., 2009 | AM260938 |
RHCE*01.26 | c.872C>T | 6 | p.Pro291Leu |
| Asian: unknown | rs374399829 | RH:5 (e+ weak) |
|
|
|
| Doscher et al., 2009 | AM183927 |
RHCE*01.27 | c.1154G>C | 9 | p.Gly385Ala |
| Asian: unknown | rs1412021250 | RH:5 (e+ weak) |
|
|
|
| Doscher et al., 2009 | AM295499 |
RHCE*01.28 | c.1254A>C | 10 | p.Ter418Tyr |
| Asian: unknown | not found | RH:4 (c+ weak) |
|
|
|
| Doscher et al., 2009 | AM295503 |
RHCE*01.29 | RHD exons 4-9 | 4-9 |
| RHCE*ceBOL | Asian: unknown | NA | RH:4,–5 (c+e–) |
|
|
|
| Cherif-Zahar et al., 1994 | not found |
RHCE*01.30 | c.526G>A | 4 | p.Ala176Thr |
| Asian: unknown | rs753965768 | RH:5 (e+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*01.31 | c.695T>C | 5 | p.Ile232Thr |
| Asian: unknown | not found | RH:5 (e+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*01.32 | c.827C>A | 6 | p.Ala276Glu |
| Asian: unknown | not found |
|
|
|
|
| Pham et al., 2011 | not found |
RHCE*01.33 | c.506T>C | 4 | p.Leu169Pro |
|
| not found | RH:5 (e+ partial, weak to neg) |
|
|
|
| Vege et al., 2010 (abstract) | KX714949 |
RHCE*01.34 | RHD exons 4-7 | 4-7 |
| Haplotype Dc– |
| NA | RH:4 (c+ partial) | Made antibody to high-frequency antigen |
|
|
| Lomas-Francis et al., 2014 (abstract) | KY652756 |
RHCE*01.35 | c.202A>G | 2 | p.Asn68Asp | (ce in trans) |
| rs772058645 |
|
|
|
|
| Goldman et al., 2016 | KP136911 |
RHCE*01.36 | c.307C>T | 2 | p.Pro103Ser | (C in trans) |
| rs676785 | RH:–4 (c–) |
|
|
|
| Goldman et al., 2016 | KP136912 |
RHCE*01.37 | c.697C>G | 5 | p.Gln233Glu | (ce in trans) |
| rs142246017 |
|
|
|
| Reported as weakly reactive with anti-D in absence of RHD | Goldman et al., 2016 | KP136915 |
RHCE*01.38 | c.1-10C>T | 5’UTR | promoter region |
|
| rs369957834 | RH:5 (e+ weak) |
|
|
|
| Doescher et al., 2009 | FM866412 |
RHCE*01.39 | c.308C>T | 2 | p.Pro103Leu |
|
| rs747882675 | RH:2 (C+ weak) |
|
|
|
| Stegmann et al., 2016 | KU319432 |
RHCE*01.40 | c.340C>T | 3 | p.Arg114Trp |
|
| rs148487630 | RH:4 (c+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | KR060081 Vrignaud, C et al. |
RHCE*01.41 | c.114A>C | 2 | p.Leu38Phe |
|
| not found | RH:–8 (Cw–) |
|
|
| RH:–8 (Cw–) and weakly reactive with three examples of anti-RH9 (Cx) | Poole et al. 2012 | not found |
RHCE*01.42 | c.508A>G | 4 | p.Arg170Gly |
|
| not found | c+e+ |
|
|
| reactive with anti-D (MS-26, HM10, ESD1, HM16) in the absence of RHD | Vrignaud et al. 2018 Transfusion | KX236061 |
RHCE*01.43 | c.499A>G | 4 | p.Met167Val |
|
| rs779408591 | RH:3 (E+ weak to neg) |
|
|
|
| Durieux-Roussel et al. 2021El Housse et al., 2019 | not found |
RHCE*01.44 | RHD exons 5-6 | 5 and 6 |
|
|
| NA | RH:4 (c+ partial, weak) |
|
|
|
| Aeschlimann et al 2019 Transfusion (abstract) | MW349828 |
Nulls | |||||||||||||
RHCE*01N.01 | c.80_84delTCTTC | 1 | p.Tyr29Phefs*5 |
|
| not found | RH:–4,–5,–17 (c–e–) |
| first found in a sample with anti-Rh17 and anti-Rh29 | anti-RH17: no to severe HDFN |
| Kato-Yamazaki et al., 2000 | not found |
RHCE*01N.02 | c.963delG | 7 | p.Iso322Phefs*37 |
|
| not found | RH:–4,–5,–17 (c–e–) |
| anti-Rh17, anti-Rh29 | anti-RH17: no to severe HDFN |
| Rosa et al., 2005 | not found |
RHCE*01N.03 | c.634+1G>T | Intron 4 | Splice site |
|
| not found | RH:–4,–5,–17 (c–e–) |
| anti-Rh17, anti-Rh29 | anti-RH17: no to severe HDFN |
| Cherif-Zahar et al., 1998 | not found |
RHCE*01N.04 | c.676delG | 5 | p.Ala226Leufs*3 |
|
| not found | RH:–4,–5,–17 (c–e–), inferred |
|
|
|
| Aeschlimann et al. 2018 | KY652755 |
RHCE*01N.05 | c.335+3A>T | Intron 2 | Splice site |
|
| not found | RH:–5 (e–) |
|
|
|
| Aeschlimann et al. 2018 | KX714951 |
RHCE*01N.06 | c.679_683delCTGCT | 5 | p.Leu227Glufs*89 |
|
| not found | RH:–4,–5,–17 (c–e–) |
|
|
|
| Pham et al., Transfusion 2013 | not found |
RHCE*01N.07 | c.1074-2A>G | Intron 7 | Splice site |
|
| not found | RH:–4 (c–) |
|
|
|
| Pham et al., Transfusion 2013 | not found |
RHCE*01N.08 | c.801+1G>A | 5 | splice site |
|
| not found | RH:–4,–5,–17 (c–e–) |
|
|
|
| Kulkarni et al., 2017 | KY229720 |
RHCE*01N.09 | c.1044_1050dupGCTTCAT | 7 | p.Thr351Alafs*52 |
|
| not found | RH:–4,–5,–17 (c–e–) | Made anti-RH29 |
|
|
| Silvy et al., 2015 | not found |
RHCE*01N.10 | c.807T>A | 6 | p.Tyr269Ter |
|
| rs780267740 | RH:–4,–5 (c–e–) |
|
|
| possible trace expression of RhCE antigens | Thonier et al., 2017 (abstract) | not found |
RHCE*01N.11 | c.1154-1G>A | intron 8 |
|
|
| not found | RH:–4 (c–) |
|
|
|
| Vege et al 2020 Transfusion (abstract) | MT374825 |
RHCE*02 or | Reference nucleotides |
|
|
|
| | RH:2 or C |
|
|
|
| Mouro et al., 1993 | BC075081 |
RHCE*02.01 | c.340C>T | 3 | p.Arg114Trp | RHCE*CeMA | Asian: unknown | rs148487630 | RH:2 (C+ weak to neg) |
|
|
|
| Noizat-Pirenne et al., 2002 | AJ548431 |
RHCE*02.02 | c.667G>T | 5 | p.Val223Phe | RHCE*CeFV | Asian: unknown | rs147357308 | RH:2 (C+) |
|
|
|
| Bugert et al., 2009 | AJ867777 |
RHCE*02.03 | c.365C>T | 3 | p.Ser122Leu | RHCE*CeJAHK | Asian: unknown | rs201407774 | RH:2 (C+ weak to neg) |
|
|
|
| Scharberg et al., 2005 | AM999773 |
RHCE*02.04 | c.667G>T | 5 | p.Val223Phe | RHCE*CeVA | Asian: unknown | rs147357308 | RH:2 (C+ partial, weak to neg) |
|
|
|
| Noizat-Pirenne et al., 2002 | not found |
RHCE*02.04.01 | c.667G>T | 5 | p.Val223Phe |
|
| rs147357308 | RH:2 (C+ weak) |
|
|
|
| Doescher et al., 2009 | AM999774 |
RHCE*02.05 | c.501G>A | 4 | p.Met167Ile | RHCE*CePARG |
| not found | RH:60 (PARG+) |
|
|
|
| Scharberg et al., 2017 | not found |
RHCE*02.08.01 | c.122A>G | 1 | p.Gln41Arg | RHCE*CeCW | Asian: unknown | rs138268848 | RH:2 (C+ partial) | anti-RH51 like (anti-MAR like) | Anti-RH2 (-C), anti-RH7 (-Ce or -rhi) | anti-RH8 (anti-Cw): no to severe HDFN |
| Mouro et al., 1995 | not found |
RHCE*02.08.02 | c.122A>G | 1 | p.Gln41Arg | RHCE*CeNR | Asian: unknown | rs138268848 | RH:8 (Cw+) |
|
|
|
| Westhoff et al., 2004 | not found |
RHCE*02.09 | c.106G>A | 1 | p.Ala36Thr | RHCE*CeCX | Asian: unknown | rs145034271 | RH:2 (C+ partial) | anti-RH51 like (anti-MAR like) | Anti-RH2 (-C), anti-RH7 (-Ce or -rhi) | anti-RH9 (anti-Cx): no to severe HDFN |
| Mouro et al., 1995 | not found |
RHCE*02.10.01 | c.505C>A | 4 | p.Leu169Met | RHCE*CeRN | Asian: none | rs1132761 | RH:2 (C+ partial, weak to neg)
| C | Anti-RH2 (anti-C), anti-RH46 (anti-Sec) | Anti-RH46 (anti-Sec) and anti-RH2 (anti-C) are clinically significant. |
| Rouillac et al., 1996 | not found |
RHCE*02.10.02 | c.455C>A | 3 | p.Thr152Asn | RHCE*CeRN.02 | Asian: none | rs35109888 | RH:2 (C+ partial, weak to neg) | C | Anti-RH2 (-C), anti-RH46 (-Sec) | Anti-RH46 (-Sec) and anti-RH2 (-C) are clinically significant. |
| Rouillac et al., 1996 | not found |
RHCE*02.11 | c.286G>A | 2 | p.Gly96Ser |
| Asian: unknown | rs144348222 | RH:2 (C+ weak) |
|
|
|
| Doscher et al., 2009 | AM295502 |
RHCE*02.12 | c.344T>G | 3 | p.Leu115Arg |
| Asian: unknown | not found | RH:2 (C+ weak) |
|
|
|
| Doscher et al., 2009 | AJ867774 |
RHCE*02.13 | c.364T>C | 3 | p.Ser122Pro |
| Asian: unknown | not found | RH:5 (e+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486157 |
RHCE*02.14 | c.497A>T | 4 | p.His166Leu |
| Asian: unknown | not found | RH:2 (C+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486159 |
RHCE*02.15 | c.689G>C | 5 | p.Ser230Thr |
| Asian: unknown | not found | RH:5 (e+ weak) |
|
|
|
| Doscher et al., 2009 | AM182449 |
RHCE*02.16 | c.728A>G | 5 | p.Tyr243Cys |
| Asian: unknown | rs555090649 | RH:2 (C+ weak) |
|
|
|
| Doscher et al., 2009 | FM165579 |
RHCE*02.17 | c.800T>A | 5 | p.Met267Lys |
| Asian: unknown | rs1132764 | RH:5 (e+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486164 |
RHCE*02.18 | c.890T>C | 6 | p.Leu297Pro |
| Asian: unknown | rs763017817 | RH:2 (C+ weak) |
|
|
|
| Doscher et al., 2009 | AM295501 |
RHCE*02.19 | c.464T>G | 3 | p.Met155Arg |
| Asian: unknown | not found | RH:5 (e+ weak) |
|
|
|
| Doscher et al., 2009 | AM295506 |
RHCE*02.20 | c.79_81delCTC | 1 | p.Leu27del |
| Asian: unknown | not found | RH:2 (C+ weak) |
|
|
|
| Doscher et al., 2009 | AM410878 |
RHCE*02.21 | c.527C>T | 4 | p.Ala176Val |
| Asian: unknown | not found | RH:2 (C+ weak) |
|
|
|
| Pham et al., 2011 | KM975479 |
RHCE*02.22 | c.667G>T | 5 | p.Val223Phe |
| Asian: unknown | rs147357308 | RH:2 (C+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*02.23 | c.941T>C | 7 | p.Val314Ala |
| Asian: unknown | rs79321360 | RH:2 (C+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*02.24 | c.1007G>A | 7 | p.Gly336Asp |
| Asian: unknown | rs760319839 | RH:2 (C+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*02.25 | c.1007G>T | 7 | p.Gly336Val |
| Asian: unknown | rs760319839 | RH:2 (C+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*02.26 | c.460A>G | 3 | p.Arg154Gly |
|
| rs755299894 | RH:2 (C+ weak) |
|
|
|
| Hellberg et al., 2016 | KU744002 |
RHCE*02.27 | c.375C>G | 3 | p.Ile125Met |
| Asian: rare | rs143715642 | RH:2 (C+ weak) |
|
|
|
| Vrignaud et al. 2014Vege et al. 2010 (Transfusion, abstract) | KM078027 |
RHCE*02.28 | c.919G>A | 6 | p.Gly307Arg |
|
| rs200950594 | RH:2,5 (C+e+) | Made antibody to high in Rh |
|
| Surprisingly RH:9 (Cx+) in the absence of c.106A | Vege et al., 2010 (abstract) | KY190222 |
RHCE*02.29 | c.674C>G | 5 | p.Ser225Cys |
|
| rs200087488 | RH:2 (C+) |
|
|
| RH3 (E): 0 to 4+ depending on reagent, in the absence of c.676C | Vege et al., 2012 (abstract) | KY190223 |
RHCE*02.30 | c.733C>G | 5 | p.Leu245Val |
|
| rs1053361 | RH:2,5 (C+e+) |
|
|
|
| Goldman et al., 2016 | KP136918 |
RHCE*02.31 | c.487-5T>G | Intron 3 | Splice site |
|
| rs776819527 | RH:2 (C+ weak) |
|
|
|
| Doescher et al., 2009 | FM866415 |
RHCE*02.32 | c.1228-2A>G | Intron 9 | Splice site |
|
| not found | RH:2 (C+ weak) |
|
|
|
| Doescher et al., 2009 | FM866417 |
RHCE*02.33 | c.98A>C | 1 | p.His33Pro |
|
| not found | RH:2 (C+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*02.34 | c.473G>A | 3 | p.Ser158Asn |
|
| rs758173067 | RH:2 (C+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*02.35 | c.491A>G | 4 | p.Asp164Gly |
|
| rs548044758 | RH:2 (C+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*02.36 | c.494A>C | 4 | p.Tyr165Ser |
|
| rs746303049 | RH:2 (C+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*02.37 | Lacking the 109bp insert | intron 2 |
|
|
|
| RH:2 (C+) |
|
|
|
| Vege et al. 2018 Transfusion (abstract) | not found |
Nulls | |||||||||||||
RHCE*02N.01 | c.966_968delinsC | 7 | p.His323Profs*77 |
|
| not found | RH:–2,–5,–17 (C–e–) |
| Anti-Rh17? |
|
| Cherif-Zahar et al., 1998Huang et al., 1998 | not found |
RHCE*02N.02 | c.659G>A | 5 | p.Trp220Ter |
|
| not found | RH:–2 (C–) |
|
|
|
| Aeschlimann et al. 2018 | KX714950 |
RHCE*02N.03 | c.486+1G>A | Intron 3 | Splice site |
|
| rs753832633 | RH:–2 (C–) |
|
|
|
| Aeschlimann et al. 2018 | KP334130 |
RHCE*02N.04 | c.93insT | 1 | p.Thr32Tyrfs*3 | Reported as c.93_94insT |
| not found | RH:–2,–5 (C–e–) |
|
|
|
| Ochoa-Garay et al., 2013Issitt et al. 1987 (Abstract) | not found |
RHCE*02N.05 | c.377C>G | 3 | p.Ser126Ter |
|
| not found | RH:–2,–5 (C–e–) |
|
|
|
| Goldman et al., 2016 | KP136914 |
RHCE*02N.06 | c.148+5G>A | Intron 1 | Splice site |
|
| rs756955857 | RH:–2,–5,–17 (C–e–) |
|
|
|
| Ochoa-Garay et al., 2013 | not found |
RHCE*02N.07 | RHD exons 3-8 | 3-8 |
|
|
| NA | RH:–2,–5,–17 (C–e–) |
|
|
|
| Silvy et al., 2012Ochoa-Garay et al., 2013 | not found |
RHCE*02N.08 | RHD exons 3-9 | 3-9 |
|
|
| NA | RH:–2,–5,–17 (C–e–) |
|
|
|
| Ochoa-Garay et al., 2013 | not found |
RHCE*02N.09 | c.938delC | 6 | p.Pro313Argfs*46 |
|
| not found | RH:–2,–5,–17 (C–e–) | Anti-RH17 |
| Hemolytic transfusion reaction |
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*02N.10 | c.482insT | 3 | p.Asn162Glnfs37Ter |
|
| not found |
|
|
|
|
| Vege et al. 2019 Transfusion (abstract) | MK090017 Aeschlimann J et al. |
RHCE*02N.11 | c.148G>A | 1 | p.Val50Ile |
|
| not found |
|
|
|
|
| Anderson et al, 2020 | MT210599 Vege et al. |
RHCE*02N.12 | c.1059delG | 7 | p.Trp353Ter |
|
| not found | RH:–2 (C–) |
|
|
|
| Aeschlimann et al. 2019 Transfusion (abstract) | MW355846 |
RHCE*03 or | Reference nucleotides |
|
|
|
|
| RH:4 or c |
|
|
|
| Mouro et al., 1993 |
|
RHCE*03.01 | c.500T>A | 4 | p.Met167Lys | RHCE*cEEW | Asian: rare | rs140421430 | RH:3 (E+ partial, weak to neg) | E | Anti-E |
| E type I | Noizat-Pirenne et al., 1998Strobel et al., 2004 | not found |
RHCE*03.02 | RHD exons 1-3 | 1-3 |
| RHCE*cEKK | Asian: rare | NA | RH:3 (E+ partial, weak to neg) |
|
|
| E type II | Noizat-Pirenne et al., 1998Kashiwase et al., 2001 | AB049753 |
RHCE*03.03 | c.697C>G | 5 | p.Gln233Glu | RHCE*cEFM | Asian: rare | rs142246017 | RH:3 (E+ partial, weak to neg) |
| no |
| E type III | Noizat-Pirenne et al., 1998Kashiwase et al., 2001 | AB018644 |
RHCE*03.03.02 | c.697C>G | 5 | p.Gln233Glu |
|
| rs142246017 | RH:3 (E+ partial, weak to neg) |
|
|
|
| Vege et al., 2010 (abstract) | KY369956 |
RHCE*03.03.03 | c.697C>G | 5 | p.Gln233Glu |
|
| rs142246017 | RH:3 (E+ partial, weak to neg) |
|
|
| RH3 (E): | Vege et al. 2018 Transfusion (abstract) | MK934127 |
RHCE*03.04 | c.602G>C | 4 | p.Arg201Thr | RHCE*cEIV | Asian: unknown | rs141398055 | RH:3 (E+ partial, weak to neg) |
| no |
| E type IV | Noizat-Pirenne et al., 1999 (abstract) | FJ486161 |
RHCE*03.05 | c.461G>C | 3 | p.Arg154Thr | RHCE*cEKH | Asian: rare | rs747471048 | RH:3 (E+ partial, weak to neg) | E | Anti-E |
| E type V | Kashiwase et al., 2001 | AB018645 |
RHCE*03.06 | c.28C>T | 1 | p.Arg10Trp |
| Asian: unknown | rs749601047 | RH:3 (E+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486155 |
RHCE*03.07 | c.344T>C | 3 | p.Leu115Pro |
| Asian: unknown | not found | RH:3 (E+ weak) |
|
|
|
| Doscher et al., 2009Bugert et al., 2009 | FJ486156 |
RHCE*03.08 | c.356G>A | 3 | p.Ser119Asn |
|
| rs777819701 | RH:3 (E+ weak) |
|
|
|
| Doscher et al., 2009 | AM295505 |
RHCE*03.09 | c.374T>A | 3 | p.Ile125Asn |
| Asian: unknown | not found | RH:3 (E+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486158 |
RHCE*03.10 | c.506T>A | 4 | p.Leu169Gln |
| Asian: unknown | not found | RH:3 (E+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486160 |
RHCE*03.11 | c.908T>A | 6 | p.Leu303Gln |
| Asian: unknown | not found | RH:3 (E+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486165 |
RHCE*03.12 | c.464T>G | 3 | p.Met155Arg |
| Asian: unknown | not found | RH:3 (E+ weak) |
|
|
|
| Doscher et al., 2009 | AM183926 |
RHCE*03.13 | c.728A>G | 5 | p.Tyr243Cys |
| Asian: unknown | rs555090649 | RH:3 (E+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*03.14 | c.734T>C | 5 | p.Leu245Pro |
| Asian: unknown | not found | RH:3 (E+ very weak to neg) |
|
|
|
| Silvy et al., 2013 | not found |
RHCE*03.15.01 | c.380C>T | 3 | p.Ala127Val | RHCE*cE BA |
| rs1053346 | RH:3 (E+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*03.15.02 | c.361A>T | 3 | p.Met121Leu | RHCE*cE JU | Asian: unknown | rs1053345 | RH:3 (E+ weak) |
|
|
|
| Pham et al., 2011 | not found |
RHCE*03.16 | c.94A>G | 1 | p.Thr32Ala | RHCE*cE TA |
| rs760999674 | RH:4 (c+ weak) |
|
|
| anti-RH4 (anti-c) clone 951 non-reactive | Yassai et al., 2015 | KP271157 |
RHCE*03.17 | c.520G>A | 4 | p.Val174Met |
|
| rs146306079 | RH:3 (E+ partial) |
|
|
|
| Vege et al., 2010 (abstract) | KY190221 |
RHCE*03.18 | c.48G>C | 1 | p.Trp16Cys |
|
| rs586178 | RH:3 (E+) |
|
|
|
| Vege et al., 2010 (abstract) | KY228976 |
RHCE*03.19 | c.84C>A | 1 | p.Phe28Leu |
|
| not found | RH:3 (E+ weak to neg) |
|
|
| RH3 (E): 0 to 1+ depending on reagent | Goldman et al., 2016Henny et al. 2014 | KP136913 |
RHCE*03.20 | c.149-1G>A | Intron 1 | Splice site |
|
| not found | RH:3 (E+ weak to neg) |
|
|
|
| Doescher et al., 2009 | FM866414 |
RHCE*03.21 | c.527C>T | 4 | p.Ala176Val |
|
| not found | RH:3 (E+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*03.22 | c.208C>T | 2 | p.Arg70Trp |
|
| rs1239729684 | RH:3 (E+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*03.23 | c.774T>A | 5 | Silent |
|
| not found | RH:3 (E+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*03.24 | c.1130A>T | 8 | p.Ala377Val |
|
| not found | RH:3 (E+ weak) |
|
|
|
| Vrignaud et al., 2014 (abstract) | not found |
RHCE*03.26 | c.48G>C | 1 | p.Trp16Cys |
|
| rs586178 | RH:2 (C+ weak to neg) |
|
|
| RH:2 (C): neg to 3+ depending on reagent | Vege et al. 2018 Transfusion (abstract) | MG434498 |
Nulls | |||||||||||||
RHCE*03N.01 | c.350_358delCCATGAGTG | 3 | p.Arg120_ Ser122del | RHCE*cEMI | Asian: unknown | not found | RH:–3 (E–) |
| Anti-Rh17? |
|
| Noizat-Pirenne et al., 2001 | not found |
RHCE*03N.02 | c.907delC | 6 | p.Leu303Ter |
| Asian: unknown | rs747976226 | RH:–3,–4,–17 (E–c–) |
|
|
|
| Westhoff et al., 2011 | GU563377 |
RHCE*03N.03 | c.554G>A | 4 | p.Trp185Ter |
|
| rs1395012563 | RH:–3,–4 (E–c–) |
|
|
|
| Paccapelo et al., 2016 (abstract) | not found |
RHCE*03N.04 | c.486+5G>A | Intron 3 | Splice site |
|
| not found | RH:–3,–4,–17 (E–c–) | made Anti-RH17 |
|
|
| Pham et al., 2013 | not found |
RHCE*03N.05 | c.221G>A | 2 | p.Trp74Ter |
|
| rs1044945369 | RH:–3,–4,–17 (E–c–) |
|
|
|
| Ochoa-Garay et al., 2013 | not found |
RHCE*03N.06 | c.200C>A | 2 | p.Ser67Ter |
|
| not found | RH:–3,–4 (E–c–) |
|
|
|
| Vege et al. 2020 Transfusion (abstract) | MT374824 |
RHCE*03N.07 | c.659G>A | 5 | p.Trp220Ter |
|
| not found | RH:–3,–4,–17 (E–c–) |
| anti-RH17? |
|
| Paccapello et al. 2018 Transfusion (abstract) | not found |
RHCE*CE or | Reference nucleotides |
|
|
|
|
| RH:2 or C |
|
|
|
| Mouro et al., 1993 |
|
RHCE*04.01 | c.722C>T | 5 | p.Thr241Ile |
| Asian: unknown | rs751751505 | RH:2 (C+ weak) |
|
|
|
| Bugert et al., 2009 | FJ486163 |
RHCE*04.02 | c.380C>A | 3 | p.Ala127Glu |
|
| rs1053346 | RH:2 (C+ weak to neg) |
|
|
| RH2 (C): positive only by IAT and ads/elu | Vege et al. 2019 Transfusion (abstract) | MH807721 |