RHCE Table

Results include both upper and lowercase alleles.

Allele nameNucleotideExonAmino AcidReported as: Linked to:Ethnicity & Frequencyrs numberAntigenAntibodySpecificityClinical significanceMisc (phenotype)Reference LinksGenBank ID

RHCE*01 or
RHCE*ce
RHCE*c
RHCE*e

Reference nucleotides
c.307C
c.676G


2
5


p.Pro103
p.Ala226

 

 


rs676785 
rs609320

 

 

 

 

RH:4 or c
RH:5 or e
RH:6 or f (ce)

Mouro et al., 1993

Reference Sequence
NG_009208.3

RHCE*01.01
RHCE*ce.01

c.48G>C

1

p.Trp16Cys

 

Asian
Black
Caucasian

rs586178

frequently weak e

no

auto anti-e possible

none known

 

Westhoff et al., 2001

DQ266400
Westhoff et al.

RHCE*01.02.01
RHCE*ce.02.01

c.48G>C
c.1025C>T

1
7

p.Trp16Cys
p.Thr342Ile

RHCE*ceTI often linked to RHD*DIVa

Asian
Black
Caucasian

rs586178
rs1053374

frequently weak e

c and e

anti-c

 

partial e partial c

Westhoff et al., 2013

KY369953
Vege et al.

RHCE*01.02.02
RHCE*ce.02.02

c.48G>C
c.150C>T
c.178C>A
c.201A>G
c.203A>G
c.307C>T
c.1025C>T

1
2




7

p.Trp16Cys
silent
p.Leu60Ile
silent
p.Asn68Ser
p.Pro103Ser
p.Thr342Ilep

RHCE*ceTI (Dex2) reported with RHD*DIVa

 

rs586178
rs200955066
rs181860403
rs1053343
rs1053344
rs676785 
rs1053374

 

 

 

 

 

Ba et al., 2015

LN680105
Ba et al.

RHCE*01.03
RHCE*ce.03

c.1025C>T

7

p.Thr342Ile

reported with DIIIa

Asian: unknown
Black: rare
Caucasian: unknown

rs1053374

 

 

 

 

partial e

Westhoff et al., 2010

MH717897
Vege et al.

RHCE*01.04.01
RHCE*ce.04.01

c.48G>C
c.712A>G
c.733C>G
c.787A>G
c.800T>A
c.916A>G

1
5



6

p.Trp16Cys
p.Met238Val
p.Leu245Val
p.Arg263Gly
p.Met267Lys
p.Ile306Val

RHCE*ceAR often linked to RHD*DAR

Asian: none
Black: some
Caucasian: none

rs586178
rs144163296
rs1053361
rs1132763
rs1132764
rs1132765

frequently weak e

c and e

anti-c anti-e
anti-RH19 (-hrS)
anti-RH18 (-Hr)

Transfusion reaction reported DAT+ to Mild HDFN

RH:10,─20 (V+w VS–)
RH:─19 (hrS–)
partial e

Hemker et al., 1999

 

RHCE*01.04.02
RHCE*ce.04.02

c.48G>C
c.697C>G
c.712A>G
c.733C>G
c.787A>G
c.800T>A
c.916A>G

1
5




6

p.Trp16Cys
p.Gln233Glu
p.Met238Val
p.Leu245Val
p.Arg263Gly
p.Met267Lys
p.Ile306Val

RHCE*ceAR+697G

 

rs586178
rs142246017
rs144163296
rs1053361
rs1132763
rs1132764
rs1132765

 

 

 

 

partial e

Vege et al., 2010 (abstract)

KY369958
Vege et al.

RHCE*01.04.03
RHCE*ce.04.03

c.48G>C
c.455C>A
c.712A>G
c.733C>G
c.787A>G
c.800T>A
c.916A>G

1
3
5



6

p.Trp16Cys
p.Thr152Asn
p.Met238Val
p.Leu245Val
p.Arg263Gly
p.Met267Lys
p.Ile306Val

RHCE*ceAR+455A

 

rs586178
rs35109888
rs144163296
rs1053361
rs1132763
rs1132764
rs1132765

 

 

 

 

 

Vege et al., 2010 (abstract)

KY369957
Vege et al.

RHCE*01.05.01
RHCE*ce.05.01

c.48G>C
c.712A>G
c.787A>G
c.800T>A

1
5

p.Trp16Cys
p.Met238Val
p.Arg263Gly
p.Met267Lys

RHCE*ceEK often linked to RHD*DAR

Asian: unknown
Black: some
Caucasian: none

rs586178
rs144163296
rs1132763
rs1132764

Frequently weak e

c and e

anti-c anti-e
anti-RH19(-hrS)
anti-RH18 (-Hr)

Transfusion reaction reported DAT+ to Mild HDFN

RH:─19 (hrS–)
partial e partial c

Noizat-Pirenne et al., 2002

AF510065
Noizat-Pirenne et al.

KU556685
Flegel et al.

RHCE*01.06.01
RHCE*ce.06.01

c.254C>G

2

p.Ala85Gly

RHCE*ceAG

Asian: unknown
Black: some
Caucasian: none

rs57992529

weak e

e

anti-e

not known

RH:─59 (CEAG–)
RH:─31 (hrB–)
partial e

Westhoff et al., 2015

GU810838
Westhoff et al.

RHCE*01.06.02
RHCE*ce.06.02

c.254C>G
c.733C>G

2
5

p.Ala85Gly
p.Leu245Val

RHCE*ceAG.02 733C>G also in trans

 

rs57992529
rs1053361

 

 

 

 

Not tested
V and VS not informative

Keller et al., 2014

 

RHCE*01.06.03
RHCE*ce.06.03

c.254C>G
c.733C>G
c.941T>C

2
5
7

p.Ala85Gly
p.Leu245Val
p.Val314Ala

RHCE*ceAG.03

 

rs57992529
rs1053361
rs79321360

 

 

 

 

Not tested

Westhoff et al., 2015

KY243887
Vege et al.

RHCE*01.06.04
RHCE*ce.06.04

c.254C>G
c.697C>G

2
5

p.Ala85Gly
p.Gln233Glu

RHCE*ceAG.04

 

rs57992529
rs142246017

 

 

 

 

 

Westhoff et al., 2015

KY243888
Vege et al.

RHCE*01.06.05
RHCE*ce.06.05

c.254C>G
c.307C>T

2

p.Ala85Gly
p.Pro103Ser

RHCE*ceAG.05 C+ robust
Linked to RHD psuedogene African American

 

rs57992529
rs676785

 

 

 

 

RH:2 (partial C+) e+

Westhoff et al., 2015

KY369954
Vege et al.

RHCE*01.07.01
RHCE*ce.07.01

c.48G>C
c.667G>T

1
5

p.Trp16Cys
p.Val223Phe

RHCE*ceMO often linked to RHD*DAU0

Asian: unknown
Black: some
Caucasian: some

rs586178
rs147357308

weak e

c and e

anti-c and -e

not known

RH:─19 (hrS–)
RH:─31 (hrB–)
RH: ─61 (CEVF–)
partial e partial c

 

RHCE*01.07.02
RHCE*ce.07.02

c.667G>T

5

p.Val223Phe

RHCE*ceMO.02 without 16Cys less often seen than ceMO.01
but also often with RHD*DAU0

Asian: unknown
Black: rare
Caucasian: none

rs147357308

 

 

 

 

RH:─19 (hrS–)
RH:─31 (hrB–)
RH: ─61 (CEVF–)
partial e partial c

Noizat-Pirenne et al., 2001

 

RHCE*01.08
RHCE*ce.08

c.48G>C
c.712A>G
c.818C>T
c.1132C>G

1
5
6
8

p.Trp16Cys
p.Met238Val
p.Ala273Val
p.Leu378Val

RHCE*ceBI often linked to RHD*DOL

Asian: unknown
Black: some
Caucasian: unknown

rs586178
rs144163296
rs147094099
rs138917454

frequently weak e

e

anti-e
anti-RH19 (-hrS)
anti-RH18 (-Hr)

not known

RH:─19 (hrS–)
RH:49 (STEM+) e+/-

Noizat-Pirenne et al., 2002

AF510066
Noizat-Pirenne et al.

RHCE*01.09
RHCE*ce.09

c.48G>C
c.712A>G
c.818C>T

1
5
6

p.Trp16Cys
p.Met238Val
p.Ala273Val

RHCE*ceSM

Asian: unknown
Black: some
Caucasian: unknown

rs586178
rs144163296
rs147094099

not known

not known

not known

not known

RH:─19 (hrS–)
Rh:49+w (STEM+w) e+/–

Reid et al., 2013

GU474431
Halter Hipsky et al.

RHCE*01.10.01
RHCE*ce.10.01

c.48G>C
c.365C>T

1
3

p.Trp16Cys
p.Ser122Leu

RHCE*ceSL
some alleles have a silent 105C>T change

Asian: none
Black: none
Caucasian: rare

rs586178
rs201407774

frequently weak e

not known

not known

 

e+w weak
reactivity with some anti-D monoclonal

Chen et al., 2006

 

RHCE*01.10.02
RHCE*ce.10.02

c.365C>T

3

p.Ser122Leu

RHCE*ceSL.02

Asian: unknown
Black: unknown
Caucasian: rare

rs201407774

not known

not known

not known

 

e+w
(Few monoclonal anti-D weakly cross-react)

Chen et al., 2006

AM072960
Chen et al.

RHCE*01.11
RHCE*ce.11

c.461G>C

3

p.Arg154Thr

RHCE*ceRT

Asian: rare
Black: unknown
Caucasian: rare

rs747471048

e+w

not known

not known

 

e+w
(Some monoclonal anti-D weakly cross-react )

Wager et al., 2003

AM072961
Wagner et al.

RHCE*01.12
RHCE*ce.12

c.48G>C
c.538G>C

1
4

p.Trp16Cys
p.Gly180Arg

RHCE*ceRA

Asian: rare
Black: unknown
Caucasian: unknown

rs586178
not found

e weak

not known

not known

not known

e+w

Noizat-Pirenne et al., 2006

 

RHCE*01.13
RHCE*ce.13

c.685_687delAGA

5

p.Arg229del

RHCE*ceBP

Asian: rare
Black: unknown
Caucasian: unknown

not found

very weak e

not known

not known

not known

e+w RH:58 (CELO+w)

Chen et al., 2004

 

RHCE*01.14
RHCE*ce.14

c.662C>G

5

p.Pro221Arg

RHCE*ceBE

Asian: rare
Black: unknown
Caucasian: unknown

rs141398055

weak c
weak e

not known

not known

not known

e+w, c+w
RH:36 (Be(a+))

Doscher et al., 2009Hue-Roye et al., 2010

AM295500
Doescher et al.

RHCE*01.15
RHCE*ce.15

c.286G>A

2

p.Gly96Ser

RHCE*ceLOCR

Asian: unknown
Black: unknown
Caucasian: rare

rs144348222

weak c

not known

not known

not known

c+w, e+w
RH:55 (LOCR+)
RH:-26

Faas et al., 1997Coghlan et al., 2006

 

RHCE*01.16
RHCE*ce.16

c.48G>C
c.1170C>T
c.1193T>A

1
9

p.Trp16Cys
silent
p.Val398Glu

with pseudogene

 

rs586178
rs630931
rs630612

 

 

 

 

e+

Lavoie et al., 2016

KU234778
Lavoie et al.

RHCE*01.20.01
RHCE*ce.20.01
RHCE*ceVS.01

c.733C>G

5

p.Leu245Val

Often linked to conventional RHD

Asian: none
Black: common
Caucasian: none

rs1053361

 

 

anti-e (auto)??

Numerous patients have received e+ blood without adverse effects

partial e partial c
RH:10,20 (V+VS+)
RH:31 weak to neg (hrB+vw/–)

Steers et al., 1996Huang et al., 1997Faas et al., 1997

 

RHCE*01.20.02
RHCE*ce.20.02
RHCE*ceVS.02

c.48G>C
c.733C>G

1
5

p.Trp16Cys
p.Leu245Val

Often linked to RHD*DIIIa or to weak partial D 4.0

Asian: none
Black: common
Caucasian: none

rs586178
rs1053361

 

 

anti-e (auto)??

Numerous patients have received e+ blood without adverse effects

partial e partial c
RH:10,20 (V+VS+)
RH:─31 (hrB–)

Faas et al., 1997

 

RHCE*01.20.03
RHCE*ce.20.03
RHCE*ceVS.03

c.48G>C
c.733C>G
c.1006G>T

1
5
7

p.Trp16Cys
p.Leu245Val
p.Gly336Cys

RHCE*ceS, often linked to RHD*DIIIa or

to hybrid RHDIII-CE-D as part of r’S type 1

or RHD-CE-D as part of type 2 haplotype

Asian: none
Black: common
Caucasian: none

rs586178
rs1053361
rs116261244

 

e and c

anti-e or anti-c

not known

when linked with hybrid D-CE-D, the C antigen is partial

partial e partial c
RH:─10,20 (V─VS+)
RH:─31 (hrB–)

Daniels et al., 1998

 

RHCE*01.20.04.01
RHCE*ce.20.04.01
RHCE*ceVS.04.01

c.48G>C
c.733C>G
c.1025C>T

1
5
7

p.Trp16Cys
p.Leu245Val
p.Thr342Ile

ceTI type 2

Asian: none
Black: some
Caucasian: none

rs586178
rs1053361
rs1053374

 

not known

not known

not known

partial e
RH:10,20 (V+VS+)
Probable RH:─31 (hrB–)

Westhoff et al., 2010

KY652757
Vege et al.

RHCE*01.20.04.02
RHCE*ce.20.04.02
RHCE*ceVS.04.02

c.48G>C
c.105C>T
c.733C>G
c.744C>T
c.1025C>T

1

5

7

p.Trp16Cys
silent
p.Leu245Val
silent
p.Thr342Ile

RHCE*ceTI type 2 as above but noting the silent changes

 

rs586178
rs142971926
rs1053361
rs149352457
rs1053374

 

 

 

 

 

 

RHCE*01.20.05
RHCE*ce.20.05
RHCE*ceVS.05

c.733C>G
c.1006G>T

5
7

p.Leu245Val
p.Gly336Cys

 

Asian: none
Black: rare
Caucasian: none

rs1053361
rs116261244

 

not known

not known

not known

partial e
RH:─10,20 (V–VS+)
RH:─31

Daniels et al., 1998

 

RHCE*01.20.06 
RHCE*ce.20.06
RHCE*ceVS.06

c.48G>C
c.697C>G
c.733C>G

1
5

p.Trp16Cys
p.Gln233Glu
p.Leu245Val

RHCE*ceCF

Asian: none
Black: some
Caucasian: none

rs586178
rs142246017
rs1053361

e +/-

c and e

anti-c anti-e

Anti-CELO DAT+, no HDFN
RH:20 (VS+)
RH:43 (Crawford+)
RH:58 (CELO)

partial c partial e
RH:43 (Crawford+)
RH:20 (VS+)
RH:-19,-31
RH:─58 (CELO–)
moderate to strongly reactive with some monoclonal anti-D

Flegel et al., 2006Hipsky et al., 2011

DQ178642
Westhoff et al.

RHCE*01.20.07

RHCE*ce.20.07

RHCE*ceVS.07

c.340C>T

c.733C>G

3

5

p.Arg114Trp

p.Leu245Val

RHCE*ceJAL

Asian: none

Black: some

Caucasian: none

rs148487630 

rs1053361

e +/- c +/-

c and e

anti-e anti-c

anti-c possibly involved in transfusion reaction

partial e partial c

RH:48,(JAL+)

RH:─57 (CEST–)

RH:20(V/VS+w)

RH:19(hrS+w/-)

RH:31(hrB+w/-)

Noizat-Pirenne et al., 2002Hustinx et al., 2009Westhoff et al., 2009

AF510067

Noizat-Pirenne et al.

RHCE*01.20.08
RHCE*ce.20.08
RHCE*ceVS.08

c.48G>C
c.733C>G
c.748G>A

1
5

p.Trp16Cys
p.Leu245Val
p.Val250Met

 

Asian: none
Black: rare
Caucasian: none

rs586178
rs1053361
not found

weak e

not known

not known

not known

e+w
RH:10,20 (V+VS+)
Probable RH:─31 (hrB−)

Noizat-Pirenne et al., 2002

AF510068
Noizat-Pirenne et al.

RHCE*01.20.09
RHCE*ce.20.09
RHCE*ceVS.09

c.48G>C
c.733C>G
c.941T>C

1
5
7

p.Trp16Cys
p.Leu245Val
p.Val314Ala

 

Asian: none
Black: rare
Caucasian: none

rs586178
rs1053361
rs79321360

weak e

e

anti-e

not known

e+w
RH:-10,20 (V–VS+)
RH:31 (hrB+w)

Hue-Roye et al., 2010 (allele reported with 1006G>T)

KX279465
Vrignaud et al.

RHCE*01.20.10
RHCE*ce.20.10
RHCE*ceVS.10

c.48G>C
c.712A>G
c.733C>G

1
5

p.Trp16Cys
p.Met238Val
p.Leu245Val

 

 

rs586178
rs144163296
rs1053361

 

 

 

 

probable partial e and partial c

Vege et al., 2010 (abstract)

KY369955
Vege et al.

RHCE*01.21.01
RHCE*ce.21.01

c.341G>A

3

p.Arg114Gln

 

Asian: one
Black: unknown
Caucasian: one

not found

weak e

not known

not known

not known

e+w
RH:48 (JAL+)

Hustinx et al., 2009

AJ548432
Wagner et al.

RHCE*01.21.02
RHCE*ce.21.02

c.48G>C
c.187G>C
c.341G>A

1
2
3

p.Trp16Cys
p.Gly63Arg
p.Arg114Gln

 

 

rs586178
not found
not found

 

 

 

 

e+w
RH:48 (JAL+)

Doescher et al., 2009

AM295498
Doescher et al.

RHCE*01.22
RHCE*ce.22

c.667G>T
c.697C>G
c.712A>G
c.733C>G
c.744T>C
c.787A>G
c.800T>A

5

p.Val223Phe
p.Gln233Glu
p.Met238Val
p.Leu245Val
silent
p.Arg263Gly
p.Met267Lys

DHAR RHCE*ceHAR

Asian: none
Black: none
Caucasian: some

rs147357308
rs142246017
rs144163296
rs1053361
rs149352457
rs1132763
rs1132764

weak e

not known

not known

not known

e+w
strongly D+ with some monoclonal anti-D
RH:33(DHAR+)
RH:50 (FPPT+)

Beckers et al., 1996

 

RHCE*01.23
RHCE*ce.23

c.649T>C

5

p.Trp217Arg

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

 

 

 

 

e+w

Bugert et al., 2009

FJ486162
Bugert et al.

RHCE*01.24
RHCE*ce.24

c.512A>G

4

p.His171Arg

 

Asian: unknown
Black: unknown
Caucasian: rare

rs781037009

weak e

 

 

 

e+w

Doscher et al.,2009

AM182448
Doescher et al.

RHCE*01.25
RHCE*ce.25

c.730G>A

5

p.Ala244Thr

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak e

 

 

 

e+w

Doscher et al., 2009

AM260938
Doescher et al.

RHCE*01.26
RHCE*ce.26

c.872C>T

6

p.Pro291Leu

 

Asian: unknown
Black: unknown
Caucasian: rare

rs374399829

weak e

 

 

 

e+w

Doscher et al., 2009

AM183927
Doescher et al.

RHCE*01.27
RHCE*ce.27

c.1154G>C

9

p.Gly385Ala

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak e

 

 

 

e+w

Doscher et al., 2009

AM295499
Doescher et al.

RHCE*01.28
RHCE*ce.28

c.1254A>C

10

p.Ter418Tyr

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak c

 

 

 

c+w

Doscher et al., 2009

AM295503
Doescher et al.

RHCE*01.29
RHCE*ce.29

RHD exons 4-9

4-9

 

RHCE*ceBOL haplotype(Dc– Bol)

Asian: unknown
Black: unknown
Caucasian: one

 

Cc+ Ee

 

 

 

c+e-

Cherif-Zahar et al., 1994

 

RHCE*01.30
RHCE*ce30

c.526G>A

4

p.Ala176Thr

 

Asian: unknown
Black: rare
Caucasian: unknown

rs753965768

weak e

 

not known

not known

e+w

Pham et al., 2011

 

RHCE*01.31
RHCE*ce31

c.695T>C

5

p.Ile232Thr

 

Asian: unknown
Black: rare
Caucasian: unknown

not found

weak e

 

 

 

 

Pham et al., 2011

 

RHCE*01.32
RHCE*ce32

c.827C>A

6

p.Ala276Gln

 

Asian: unknown
Black: rare
Caucasian: unknown

not found

 

 

 

 

 

Pham et al., 2011

 

RHCE*01.33
RHCE*ce33

c.506T>C

4

p.Leu169Pro

 

 

not found

 

 

 

 

partial e e+w/−
RH:-31 (hrB–)

Vege et al., 2010 (abstract)

KX714949
Vege, S et al.

RHCE*01.34
RHCE*ce34

RHD exons 4-7

4-7

 

Haplotype Dc− Made antibody to high

 

NA

 

 

 

 

partial c+e-

Lomas-Francis et al., 2014 (abstract)

KY652756
Vege et al.

RHCE*01.35
RHCE*ce35

c.202A>G

2

p.Asn68Asp

(ce in trans)

 

rs772058645

 

 

 

 

c+ e+

Goldman et al., 2016

KP136911
Hyland et al.

RHCE*01.36
RHCE*ce36

c.307C>T

2

p.Pro103Ser

(C in trans)

 

rs676785

 

 

 

 

c–

Goldman et al., 2016

KP136912
Cemborain et al.

RHCE*01.37
RHCE*ce37

c.697C>G
c.712A>G
c.733C>G
c.744T>C

5

p.Gln233Glu
p.Met238Val
p.Leu245Val
p.Ser248Ser

Reported as weakly reactive with anti-D in absence of RHD

 

rs142246017
rs144163296
rs1053361
rs149352457

 

 

 

 

c+ e+

Goldman et al., 2016

KP136915
Garcia et al.

RHCE*01.38
RHCE*ce38

c.1-10C>T

5’UTR

promoter region

 

 

rs369957834

 

 

 

 

weakened e

Doescher et al., 2009

FM866412
Doescher et al.

RHCE*01.39
RHCE*ce39

c.308C>T

2

p.Pro103Leu

 

 

rs747882675

 

 

 

 

C+w c-

Stegmann et al., 2016

KU319432
Ji et al.

RHCE*01.40
RHCE*ce40

c.340C>T

3

p.Arg114Trp

 

 

rs148487630

 

 

 

 

c+w

Vrignaud et al., 2014 (abstract)

 

Nulls

RHCE*01N.01
RHCE*ceN.01

c.80_84delTCTTC

1

p.Tyr29Phefs*5

 

 

not found

ce

 

first found in a sample with anti-Rh17 and anti-Rh29

no to severe HDFN

c–e–

Kato-Yamazaki et al., 2000

 

RHCE*01N.02
RHCE*ceN.02

c.963delG

7

p.Iso322Phefs*37

 

 

not found

ce

 

anti-Rh17, anti-Rh29

 

c–e–

Rosa et al., 2005

 

RHCE*01N.03
RHCE*ceN.03

c.634+1G>T

Intron 4

Splice site

 

 

not found

ce

 

anti-Rh17, anti-Rh29

 

c–e–

Cherif-Zahar et al., 1998

 

RHCE*01N.04
RHCE*ceN.04

c.676delG

5

p.Ala226Leufs*3

 

 

rs609320

 

 

 

 

c–e–

KY652755
Vege et al.

RHCE*01N.05
RHCE*ceN.05

c.335+3A>T

Intron 2

Splice site

 

 

not found

 

 

 

 

c–e–

KX714951
Vege et al.

RHCE*01N.06
RHCE*ceN.06

c.679_683delCTGCT

5

p.Leu227Glufs*89

 

 

not found

 

 

 

 

c–e–

Pham et al., Transfusion 2013

 

RHCE*01N.07
RHCE*ceN.07

c.1074-2A>G

Intron 7

Splice site

 

 

not found

 

 

 

 

c–e–

Pham et al., Transfusion 2013

 

RHCE*01N.08
RHCE*ceN.08

c.801+1G>A

5

splice site

 

 

not found

 

 

 

 

c–e–

Kulkarni et al., 2017

KY229720
Fichou et al.

RHCE*01N.09
RHCE*ceN.09

c.1044_1050dupGCTTCAT

7

p.Thr351Alafs*52

 

 

not found

 

 

 

 

c–e–

Sylvie et al., 2015

 

RHCE*01N.10
RHCE*ceN.10

c.807T>A

6

p.Tyr269Ter

 

 

rs780267740

 

 

 

 

c–e–

Thonier et al., 2017 (abstract)

 

RHCE*02 or
RHCE*Ce
RHCE*C
RHCE*e

Reference nucleotides
c.48G>C
c.150C>T
c.178C>A
c.201A>G
c.203A>G
c.307C>T
c.676G


1
2




5


p.Trp16Cys
silent
p.Leu60Ile
silent
p.Asn68Ser
p.Pro103Ser
p.Ala226

 

 

 

 

 

 

 

Ce RH:2 or
C RH:5 or
e RH:7 or
rhi(Ce)

Mouro et al., 1993

BC075081
Strausberg et al.

RHCE*02.01
RHCE*Ce.01

c.340C>T

3

p.Arg114Trp

RHCE*CeMA
RHCE*CeJAL

Asian: unknown
Black: unknown
Caucasian: rare

rs148487630

weak C+ weak e+

 

not known

not known

C+w/- e+w
RH:48(JAL+)

Noizat-Pirenne et al., 2002

AJ548431
Wagner et al.

AM183925
Doescher et al.

RHCE*02.02
RHCE*Ce.02

c.667G>T
c.697C>G
c.712A>G

5

p.Val223Phe
p.Gln233Glu
p.Met238Val

RHCE*CeFV

Asian: unknown
Black: unknown
Caucasian: rare

rs147357308
rs142246017
rs144163296

 

 

not known

not known

C+e+

Bugert et al., 2009

AJ867777
Doescher et al.

RHCE*02.03
RHCE*Ce.03

c.365C>T

3

p.Ser122Leu

RHCE*CeJAHK

Asian: unknown
Black: unknown
Caucasian: rare

rs201407774

weak C+, weak e+

 

not known

not known

C+w e+w
RH:53(JAHK+)
rG

Scharberg et al., 2005

AM999773
Doescher et al..
(called CeSI in GenBank)

RHCE*02.04
RHCE*Ce.04

c.667G>T
c.697C>G
c.712A>G
c.733C>G
c.744T>C
c.787A>G
c.800T>A

5

p.Val223Phe
p.Gln233Glu
p.Mer238Val
p.Leu245Val
silent
p.Arg263Gly
p.Met267Lys

RHCE*CeVA

Asian: unknown
Black: unknown
Caucasian: rare

rs147357308
rs142246017
rs144163296
rs1053361
rs149352457
rs1132763
rs1132764

C weak+/-

 

not known

not known

partial C+

Noizat-Pirenne et al., 2002

 

RHCE*02.04.01
RHCE*Ce.04.01

c.667G>T
c.697C>G
c.712A>G
c.733C>G
c.744T>C
c.787A>G

5

p.Val223Phe
p.Gln233Glu
p.Mer238Val
p.Leu245Val
silent
p.Arg263Gly

 

 

rs147357308
rs142246017
rs144163296
rs1053361
rs149352457
rs1132763

 

 

 

 

C+w e+w

Doescher et al., 2009

AM999774
Doescher et al.

RHCE*02.05
RHCE*Ce.05

c.501G>A

4

p.Met167Ile

RHCE*CePARG

 

not found

 

 

 

 

RH:60 (PARG+)

Scharberg et al., 2017

 

RHCE*02.08.01
RHCE*Ce.08.01

c.122A>G

1

p.Gln41Arg

RHCE*CeCW

Asian: unknown
Black: unknown
Caucasian: some

rs138268848

 

anti-51 like/MAR like

Anti-C, Anti-rhi

not known

partial C+
RH:8 (CW+)
RH:–51 (MAR–)

Mouro et al., 1995

 

RHCE*02.08.02
RHCE*Ce.08.02

c.122A>G
RHD exon 6-10

1
6-10

p.Gln41Arg

RHCE*CeNR

Asian: unknown
Black: one
Caucasian: unknown

rs138268848

 

 

 

 

RH:8 (CW+)
RH:–56 (CENR–)

Westhoff et al., 2004

 

RHCE*02.09
RHCE*Ce.09

c.106G>A

1

p.Ala36Thr

RHCE*CeCX

Asian: unknown
Black: unknown
Caucasian: uncommon

rs145034271

 

anti-51 like/MAR like

Anti-C, Anti-rhi

not known

partial C+
RH:9 (CX+)
RH:–51 (MAR–)

Mouro et al., 1995

 

RHCE*02.10.01
RHCE*Ce.10.01

c.505C>A
c.509G>T
c.514T>A
c.544A>T
c.577A>G
c.594T>A
c.602G>C

4

p.Leu169Met
p.Arg170Met
p.Phe172Ile
p.Thr182Ser
p.Lys193Glu
p.Asn198Lys
p.Arg201Thr

RHCE*CeRN

Asian: none
Black: some
Caucasian: none

rs1132761
rs1132762
rs1053349
rs1053350
not found
rs1053354
rs141398055

weak C+, weak e+

C

Anti-C, Anti-Rh46

Anti-Rh46 and anti-C are clinically significant.
No to severe HDFN

C+w/partial, e+w
RH:32 (RN)
RH:54 (DAK+)
RH:–46 (Sec–)

Rouillac et al., 1996

 

RHCE*02.10.02
RHCE*Ce.10.02

c.455C>A
c.505C>A
c.509G>T
c.514T>A
c.544A>T
c.577A>G
c.594T>A
c.602G>C

3
4

p.Thr152Asn
p.Leu169Met
p.Arg170Met
p.Phe172Ile
p.Thr182Ser
p.Lys193Glu
p.Asn198Lys
p.Arg201Thr

RHCE*CeRN.02 exists?

Asian: none
Black: some
Caucasian: none

rs35109888
rs1132761
rs1132762
rs1053349
rs1053350
not found
rs1053354
rs141398055

weak C+, weak e+

C

Anti-C, Anti-Rh46

Anti-Rh46 and anti-C are clinically significant.
No to severe HDFN

C+w/− partial,  e+w
RH:32 (RN)
RH:54 (DAK+)
RH:–46 (Sec–)

Rouillac et al., 1996

 

RHCE*02.11
RHCE*Ce.11

c.286G>A

2

p.Gly96Ser

 

Asian: unknown
Black: unknown
Caucasian: rare

rs144348222

weak C

 

 

 

C+w

Doscher et al., 2009

AM295502
Doescher et al.

RHCE*02.12
RHCE*Ce.12

c.344T>G

3

p.Leu115Arg

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak C

 

 

 

C+w

Doscher et al., 2009

AJ867774
Doescher et al.

RHCE*02.13
RHCE*Ce.13

c.364T>C

3

p.Ser122Pro

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

 

 

 

 

e+w

Bugert et al., 2009

FJ486157
Bugert et al.

RHCE*02.14
RHCE*Ce.14

c.497A>T

4

p.His166Leu

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak C

 

 

 

C+w

Bugert et al., 2009

FJ486159
Bugert et al.

RHCE*02.15
RHCE*Ce.15

c.689G>C

5

p.Ser230Thr

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak e

 

 

 

e+w

Doscher et al., 2009

AM182449
Doescher et al.

RHCE*02.16
RHCE*Ce.16

c.728A>G

5

p.Tyr243Cys

 

Asian: unknown
Black: unknown
Caucasian: rare

rs555090649

weak C, weak e

 

 

 

C+w e+w

Doscher et al., 2009

FM165579
Doescher et al.

RHCE*02.17
RHCE*Ce.17

c.800T>A

5

p.Met267Lys

 

Asian: unknown
Black: unknown
Caucasian: rare

rs1132764

 

 

 

 

e+w

Bugert et al., 2009

FJ486164
Bugert et al.

RHCE*02.18
RHCE*Ce.18

c.890T>C

6

p.Leu297Pro

 

Asian: unknown
Black: unknown
Caucasian:rare

rs763017817

weak C weak e+

 

 

 

C+w e+w

Doscher et al., 2009

AM295501
Doescher et al.

RHCE*02.19
RHCE*Ce.19

c.464T>G
c.1118C>T

3
8

p.Met155Arg
p.Ala373Val

 

Asian: unknown
Black: unknown
Caucasian: rare

not found
not found

weak e

 

 

 

e+w

Doscher et al., 2009

AM295506
Doescher et al.

RHCE*02.20
RHCE*Ce.20

c.79_81delCTC

1

p.Leu27del

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak C

 

 

 

C+w e+w

Doscher et al., 2009

AM410878
Doescher et al.

RHCE*02.21
RHCE*Ce.21

c.527C>T

4

p.Ala176Val

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak C

 

 

 

C+w

Pham et al., 2011

KM975479
Vrignaud et al.

RHCE*02.22
RHCE*Ce.22

c.667G>T

5

p.Val223Phe

 

Asian: unknown
Black: unknown
Caucasian: rare

rs147357308

weak C weak e

 

 

 

Partial e+w C+w

Pham et al., 2011

 

RHCE*02.23
RHCE*Ce.23

c.941T>C

7

p.Val314Ala

 

Asian: unknown
Black: unknown
Caucasian: rare

rs79321360

weak C

 

 

 

C+w

Pham et al., 2011

 

RHCE*02.24
RHCE*Ce.24

c.1007G>A

7

p.Gly336Asp

 

Asian: unknown
Black: unknown
Caucasian: rare

rs760319839

weak C weak e

 

 

 

C+w e+w

Pham et al., 2011

 

RHCE*02.25
RHCE*Ce.25

c.1007G>T

7

p.Gly336Val

 

Asian: unknown
Black: unknown
Caucasian: rare

rs760319839

weak C

 

 

 

C+w

Pham et al., 2011

 

RHCE*02.26
RHCE*Ce.26

c.460A>G

3

p.Arg154Gly

 

 

rs755299894

 

 

 

 

C+w e+w

Hellberg et al., 2016

KU744002
Hellber et al.

RHCE*02.27
RHCE*Ce.27

c.375C>G

3

p.Ile125Met

 

 

rs143715642

 

 

 

 

C+w e+w

Vrignaud et al., 2014 (abstract)

KM078027
Vrignaud et al.

RHCE*02.28
RHCE*Ce.28

c.919G>A

6

p.Gly307Arg

Surprisingly CX+ in absence of  c.106A
Made antibody to high in Rh

 

rs200950594

 

 

 

 

C+ e+
RH:9

Vege et al., 2010 (abstract)

KY190222
Vege et al.

RHCE*02.29
RHCE*Ce.29

c.674C>G

5

p.Ser225Cys

E: 0-4+ depending on reagent, in absence of c.676C

 

rs200087488

 

 

 

 

C+ e+ E+/–

Vege et al., 2012 (abstract)

KY190223
Vege et al.

RHCE*02.30
RHCE*Ce.30

c.733C>G

5

p.Leu245Val

 

 

rs1053361

 

 

 

 

C+ e+ V+VS+

Goldman et al., 2016

KP136918
Kalvelage et al.

RHCE*02.31
RHCE*Ce.31

c.487-5T>G

Intron 3

Splice site

 

 

rs776819527

 

 

 

 

C+w e+w

Doescher et al., 2009

FM866415
Doescher et al.

RHCE*02.32
RHCE*Ce.32

c.1228-2A>G

Intron 9

Splice site

 

 

not found

 

 

 

 

C+w

Doescher et al., 2009

FM866417
Doescher et al.

RHCE*02.33
RHCE*Ce.33

c.98A>C

1

p.His33Pro

 

 

not found

 

 

 

 

C+w

Vrignaud et al., 2014 (abstract)

 

RHCE*02.34
RHCE*Ce.34

c.473G>A

3

p.Ser158Asn

 

 

rs758173067

 

 

 

 

C+w e+w

Vrignaud et al., 2014 (abstract)

 

RHCE*02.35
RHCE*Ce.35

c.491A>G

4

p.Asp164Gly

 

 

rs548044758

 

 

 

 

C+w

Vrignaud et al., 2014 (abstract)

 

RHCE*02.36
RHCE*Ce.36

c.494A>C

4

p.Tyr165Ser

 

 

rs746303049

 

 

 

 

C+w

Vrignaud et al., 2014 (abstract)

 

Nulls

RHCE*02N.01
RHCE*CeN.01

c.966_968delinsC

7

p.His323Profs*77

 

 

not found

Ce

 

Anti-Rh17?

 

C–e–

Cherif-Zahar et al., 1998Huang et al., 1998

 

RHCE*02N.02
RHCE*CeN.02

c.659G>A

5

p.Trp220Ter

 

 

not found

 

 

 

 

C–e–

KX714950
Vege et al.

RHCE*02N.03
RHCE*CeN.03

c.486+1G>A

Intron 3

Splice site

 

 

rs753832633

 

 

 

 

C–e–

KP334130
Vege et al.

RHCE*02N.04
RHCE*CeN.04

c.93_94insT

1

p.Thr32Tyrfs*3

 

 

not found

 

 

 

 

C–e–

Ochoa-Garay et al., 2013

 

RHCE*02N.05
RHCE*CeN.05

c.377C>G

3

p.Ser126Ter

 

 

not found

 

 

 

 

C–e–

Goldman et al., 2016

KP136914
Goldman et al.

RHCE*02N.06
RHCE*CeN.06

c.148+5G>A

Intron 1

Splice site

 

 

not found

 

 

 

 

C–e–

Ochoa-Garay et al., 2013

 

RHCE*02N.07
RHCE*CeN.07

RHD exons 3-8

3-8

 

 

 

NA

 

 

 

 

C–e–

Silvy et al., 2012Ochoa-Garay et al., 2013

 

RHCE*02N.08
RHCE*CeN.08

RHD exons 3-9

3-9

 

 

 

NA

 

 

 

 

C–e–

Ochoa-Garay et al., 2013

 

RHCE*02N.09
RHCE*CeN.09

c.938delC

6

p.Pro313Argfs*46

 

 

not found

 

 

 

 

C–e–

Vrignaud et al., 2014 (abstract)

 

RHCE*03 or
RHCE*cE
RHCE*c
RHCE*E

Reference nucleotides
c.307C
c.676G>C


2
5


p.Pro103
p.Ala226Pro

 

 

 

 

 

 

 

cE
RH:4 or c
RH:3 or E
RH:27 (cE)

Mouro et al., 1993

 

RHCE*03.01
RHCE*cE.01

c.500T>A

4

p.Met167Lys

RHCE*cEEW

Asian: rare
Black: unknown
Caucasian: rare

rs140421430

E weak+/-

E

Anti-E

 

partial E
RH:11 (EW +)
E type I

Noizat-Pirenne et al., 1998Strobel et al., 2004

 

RHCE*03.02
RHCE*cE.02

RHD exons 1-3

1-3

 

RHCE*cEKK

Asian: rare
Black: unknown
Caucasian: rare

NA

E weak+/-
c weak+/-

 

 

 

partial E
c+w/− E+w/-
E type II

Noizat-Pirenne et al., 1998Kashiwase et al., 2001

AB049753
Kashiwase et al.

RHCE*03.03
RHCE*cE.03

c.697C>G
c.712A>G

5

p.Gln233Glu
p.Met238Val

RHCE*cEFM

Asian: rare
Black: unknown
Caucasian: rare

rs142246017
rs144163296

E weak +/-

 

no

 

partial E
E+w or E+/-
E type III

Kashiwase et al., 2001Noizat-Pirenne et al., 1998

AB018644
Kashiwase et al.

RHCE*03.03.02
RHCE*cE.03.02

c.697C>G
c.712A>G
c.733C>G
c.744T>C

5

p.Gln233Glu
p.Met238Val
p.Leu245Val
silent

 

 

rs142246017
rs144163296
rs1053361
rs149352457

 

 

 

 

partial E
E+/-

Vege et al., 2010 (abstract)

KY369956
Vege et al.

RHCE*03.04
RHCE*cE.04

c.602G>C

4

p.Arg201Thr

RHCE*cEIV

Asian: unknown
Black: unknown
Caucasian: rare

rs141398055

E weak +/-

 

no

 

partial E
E+w or E+/-
c+w
E type IV

Noizat-Pirenne et al., 1999 (abstract)

FJ486161
Bugert et al.

RHCE*03.05
RHCE*cE.05

c.461G>C

3

p.Arg154Thr

RHCE*cEKH

Asian: rare
Black: unknown
Caucasian: unknown

rs747471048

E weak +/-
c weak +/-

E

Anti-E

 

partial E
E+w or E+/-
c+w
E type V

Kashiwase et al., 2001

AB018645
Kashiwase et al.

RHCE*03.06
RHCE*cE.06

c.28C>T

1

p.Arg10Trp

 

Asian: unknown
Black: unknown
Caucasian: rare

rs749601047

weak c weak E

 

 

 

E+w c+w

Bugert et al., 2009

FJ486155
Bugert et al.

RHCE*03.07
RHCE*cE.07

c.344T>C

3

p.Leu115Pro

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak E+

 

 

 

E+w

Doscher et al., 2009Bugert et al., 2009

FJ486156
Bugert et al.

RHCE*03.08
RHCE*cE.08

c.356G>A

3

p.Ser119Asn

 

 

rs777819701

weak E+

 

 

 

E+w

Doscher et al., 2009

AM295505
Doescher et al.

RHCE*03.09
RHCE*cE.09

c.374T>A

3

p.Ile125Asn

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak c
weak E

 

 

 

E+w c+w

Bugert et al., 2009

FJ486158
Bugert et al.

RHCE*03.10
RHCE*cE.10

c.506T>A

4

p.Leu169Gln

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak E

 

 

 

E+w

Bugert et al., 2009

FJ486160
Bugert et al.

RHCE*03.11
RHCE*cE.11

c.908T>A

6

p.Leu303Gln

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

weak c
weak E

 

 

 

E+w c+w

Bugert et al., 2009

FJ486165
Bugert et al.

RHCE*03.12
RHCE*cE.12

c.464T>G
c.477T>G

3

p.Met155Arg
p.Asn159Lys

 

Asian: unknown
Black: unknown
Caucasian: rare

not found
not found

weak E+

 

 

 

E+w

Doscher et al., 2009

AM183926
Doescher et al.

RHCE*03.13
RHCE*cE.13

c.728A>G

5

p.Tyr243Cys

 

Asian: unknown
Black: unknown
Caucasian: rare

rs555090649

weak E weak c

 

 

 

E+w c+w

Pham et al., 2011

 

RHCE*03.14
RHCE*cE.14

c.734T>C

5

p.Leu245Pro

 

Asian: unknown
Black: unknown
Caucasian: rare

not found

E very weak+/-
weak c

 

 

 

c+w Evw−/+

Silvy et al., 2013

 

RHCE*03.15.01
RHCE*cE.15.01

c.380C>T
c.383G>A

3

p.Ala127Val
p.Gly128Asp

RHCE*cE BA

 

rs1053346
rs1053347

weak E

 

 

 

E+w

Pham et al., 2011

 

RHCE*03.15.02
RHCE*cE.15.02

c.361A>T
c.380C>T
c.383G>A

3

p.Met121Leu
p.Ala127Val
p.Gly128Asp

RHCE*cE JU

Asian: unknown
Black: unknown
Caucasian: rare

rs1053345
rs1053346
rs1053347

weak E

 

 

 

E+w

Pham et al., 2011

 

RHCE*03.16
RHCE*cE.16

c.94A>G

1

p.Thr32Ala

RHCE*cE TA
anti-c clone 951 non-reactive

 

rs760999674

 

 

 

 

c+w

Yassai et al., 2015

KP271157
Yassai et al.

RHCE*03.17
RHCE*cE.17

c.520G>A

4

p.Val174Met

 

 

rs146306079

 

 

 

 

partial E

Vege et al., 2010 (abstract)

KY190221
Vege et al.

RHCE*03.18
RHCE*cE.18

c.48G>C

1

p.Trp16Cys

 

 

rs586178

 

 

 

 

c+ E+

Vege et al., 2010 (abstract)

KY228976
Vege et al.

RHCE*03.19
RHCE*cE.19

c.84C>A

1

p.Phe28Leu

c: 0 to 3+
E: 0 to 1+ depending on reagent

 

not found

 

 

 

 

c+w/- E+w/−

Goldman et al., 2016

KP136913
Goldman et al.

LN554880
Henny et al.

RHCE*03.20
RHCE*cE.20

c.149-1G>A

Intron 1

Splice site

 

 

not found

 

 

 

 

c+w E+w+/-

Doescher et al., 2009

FM866414
Doescher et al.

RHCE*03.21
RHCE*cE.21

c.527C>T

4

p.Ala176Val

 

 

not found

 

 

 

 

E+w

Vrignaud et al., 2014 (abstract)

 

RHCE*03.22
RHCE*cE.22

c.208C>T

2

p.Arg70Trp

 

 

not found

 

 

 

 

E+w

Vrignaud et al., 2014 (abstract)

 

RHCE*03.23
RHCE*cE.23

c.774T>A
c.916A>G

5

Silent
p.Ile306Val

 

 

not found
rs1132765

 

 

 

 

E+w

Vrignaud et al., 2014 (abstract)

 

RHCE*03.24
RHCE*cE.24

c.1130A>T

8

p.Ala377Val

 

 

not found

 

 

 

 

E+w

Vrignaud et al., 2014 (abstract)

 

Nulls

RHCE*03N.01
RHCE*cEN.01

c.350_358delCCATGAGTG

3

p.Arg120_ Ser122del

RHCE*cEMI

Asian: unknown
Black: unknown
Caucasian:

not found

cE

 

Anti-Rh17?

 

c–E–

Noizat-Pirenne et al., 2001

 

RHCE*03N.02
RHCE*cEN.02

c.907delC

6

p.Leu303Ter

 

Asian: unknown
Black: unknown
Hispanic: some
Caucasian: unknown

rs747976226

cE

 

 

 

c–E–

Westhoff et al., 2011

GU563377
Westhoff et al.

RHCE*03N.03
RHCE*cEN.03

c.554G>A

4

p.Trp185Ter

 

 

not found

 

 

 

 

c–E–

Paccapelo et al., 2016 (abstract)

 

RHCE*04N.04
RHCE*cEN.04

c.486+5G>A

Intron 3

Splice site

 

 

not found

 

made Anti-RH17

 

 

c–E–

Pham et al., 2013

 

RHCE*04N.05
RHCE*cEN.05

c.221G>A

2

p.Trp74Ter

 

 

rs1044945369

 

 

 

 

c–E–

Ochoa-Garay et al., 2013

 

RHCE*CE or
RHCE*04
RHCE*C
RHCE*E

Reference nucleotides
c.48G>C
c.150C>T
c.178C>A
c.201A>G
c.203A>G
c.307C>T
c.676G>C


1
2




5


p.Trp16Cys
silent
p.Leu60Ile
silent
p.Asn68Ser
p.Pro103Ser
p.Ala226Pro

 

 

 

 

 

 

 

CE
RH:2 or C
RH:3 or E
RH:22 or CE

Mouro et al., 1993

 

RHCE*04.01
RHCE*CE.01

c.722C>T

5

p.Thr241Ile

 

Asian: unknown
Black: unknown
Caucasian: one

rs751751505

 

Weak C
E weak+/-

 

 

C+w E+/–

Bugert et al., 2009

FJ486163
Bugert et al.