RHCE Table

RHCE*01
RHCE*ce
(RHCE*c or RHCE*e if
partly characterized)

RH:4 or c
RH:5 or e
RH:6 or f (ce)

Reference Sequence
NG_009208.3

RHCE*01.01
RHCE*ce.01

c.48G>C

1

p.Trp16Cys

Asian
Black
Caucasian

rs586178

RH:5 (e+ weak)

no

auto anti-e possible

none known

DQ266400

RHCE*01.02.01
RHCE*ce.02.01
RHCE*ceTI

c.48G>C
c.1025C>T

1
7

p.Trp16Cys
p.Thr342Ile

RHD*DIVa

Asian
Black
Caucasian

rs586178
rs1053374

RH:4 (c+ weak, partial)
RH:5 (e+ weak, partial)

c and e

anti-c

KY369953

RHCE*01.02.02
RHCE*ce.02.02
RHCE*ceTI-D(2)

c.48G>C
c.150C>T
c.178C>A
c.201A>G
c.203A>G
c.307C>T
c.1025C>T

1
2




7

p.Trp16Cys
p.Val50=
p.Leu60Ile
p.Ser67=
p.Asn68Ser
p.Pro103Ser
p.Thr342Ilep

RHD*DIVa

rs586178
rs200955066
rs181860403
rs1053343
rs1053344
rs676785 
rs1053374

LN680105

RHCE*01.03
RHCE*ce.03

c.1025C>T

7

p.Thr342Ile

reported with RHD*DIIIa

Asian: unknown
Black: rare
Caucasian: unknown

rs1053374

RH:5 (e+ partial)

MH717897

RHCE*01.04.01
RHCE*ce.04.01
RHCE*ceAR

c.48G>C
c.712A>G
c.733C>G
c.787A>G
c.800T>A
c.916A>G

1
5



6

p.Trp16Cys
p.Met238Val
p.Leu245Val
p.Arg263Gly
p.Met267Lys
p.Ile306Val

RHCE*ceAR, often linked to RHD*DAR

Asian: none
Black: some
Caucasian: none

rs586178
rs144163296
rs1053361
rs1132763
rs1132764
rs1132765

RH:4 (c+ partial)
RH:5 (e+ weak, partial)
RH:10,–20 (V+ weak, VS–)
RH:–18,–19 (Hr–, hrS–)

c and e

anti-c anti-e
anti-RH19 (-hrS)
anti-RH18 (-Hr)

Transfusion reaction reported DAT+ to Mild HDFN

not found

RHCE*01.04.02
RHCE*ce.04.02

c.48G>C
c.697C>G
c.712A>G
c.733C>G
c.787A>G
c.800T>A
c.916A>G

1
5




6

p.Trp16Cys
p.Gln233Glu
p.Met238Val
p.Leu245Val
p.Arg263Gly
p.Met267Lys
p.Ile306Val

RHCE*ceAR+697G

rs586178
rs142246017
rs144163296
rs1053361
rs1132763
rs1132764
rs1132765

Inferred as
RHCE*01.04.01
RHCE*ceAR

KY369958

RHCE*01.04.03
RHCE*ce.04.03

c.48G>C
c.455C>A
c.712A>G
c.733C>G
c.787A>G
c.800T>A
c.916A>G

1
3
5



6

p.Trp16Cys
p.Thr152Asn
p.Met238Val
p.Leu245Val
p.Arg263Gly
p.Met267Lys
p.Ile306Val

RHCE*ceAR+455A

rs586178
rs35109888
rs144163296
rs1053361
rs1132763
rs1132764
rs1132765

Inferred as
RHCE*01.04.01
RHCE*ceAR

KY369957

RHCE*01.04.04
RHCE*ce.04.04

c.712A>G
c.733C>G
c.787A>G
c.800T>A
c.916A>G

5



6

p.Met238Val
p.Leu245Val
p.Arg263Gly
p.Met267Lys
p.Ile306Val

rs144163296
rs1053361
rs1132763
rs1132764
rs1132765

Inferred as
RHCE*01.04.01
RHCE*ceAR

not found

RHCE*01.05.01
RHCE*ce.05.01
RHCE*ceEK

c.48G>C
c.712A>G
c.787A>G
c.800T>A

1
5

p.Trp16Cys
p.Met238Val
p.Arg263Gly
p.Met267Lys

RHCE*ceEK, often linked to RHD*DAR

Asian: unknown
Black: some
Caucasian: none

rs586178
rs144163296
rs1132763
rs1132764

RH:4 (c+ partial)
RH:5 (e+ weak, partial)
RH:–18,–19 (Hr–, hrS–)

c and e

anti-c anti-e
anti-RH19(-hrS)
anti-RH18 (-Hr)

Transfusion reaction reported DAT+ to Mild HDFN

AF510065
KU556685

RHCE*01.05.02
RHCE*ce.05.02

c.712A>G
c.787A>G
c.800T>A

5

p.Met238Val
p.Arg263Gly
p.Met267Lys

RHCE*ceEK without 48C

rs144163296
rs1132763
rs1132764

RH:4 (c+ partial)
RH:5 (e+ partial)
RH:–18,–19 (Hr–, hrS–)

anti-RH4 (-c)
anti-18 (-Hr)
anti-19 (-hrS)

not found

RHCE*01.06.01
RHCE*ce.06.01
RHCE*ceAG

c.254C>G

2

p.Ala85Gly

RHCE*ceAG

Asian: unknown
Black: some
Caucasian: none

rs57992529

RH:5 (e+ weak, partial)
RH:–59 (CEAG–)
RH:–31 (hrB–)

e

anti-e

not known

GU810838

RHCE*01.06.02
RHCE*ce.06.02

c.254C>G
c.733C>G

2
5

p.Ala85Gly
p.Leu245Val

RHCE*ceAG.02
c.733C>G also in trans

rs57992529
rs1053361

Not tested
V and VS not informative

not found

RHCE*01.06.03
RHCE*ce.06.03

c.254C>G
c.733C>G
c.941T>C

2
5
7

p.Ala85Gly
p.Leu245Val
p.Val314Ala

RHCE*ceAG.03

rs57992529
rs1053361
rs79321360

Not tested

KY243887

RHCE*01.06.04
RHCE*ce.06.04

c.254C>G
c.697C>G

2
5

p.Ala85Gly
p.Gln233Glu

RHCE*ceAG.04

rs57992529
rs142246017

KY243888

RHCE*01.06.05
RHCE*ce.06.05

c.254C>G
c.307C>T

2

p.Ala85Gly
p.Pro103Ser

RHCE*ceAG.05
Linked to RHD*pseudogene

Black

rs57992529
rs676785

RH:2 (C+ partial, robust C+ expression)
RH:5 (e+)

robust RH:2 (C+) expression

KY369954

RHCE*01.07.01
RHCE*ce.07.01
RHCE*ceMO.01

c.48G>C
c.667G>T

1
5

p.Trp16Cys
p.Val223Phe

Reported as RHCE*ceMO, often linked to RHD*DAU0

Asian: unknown
Black: some
Caucasian: some

rs586178
rs147357308

RH:4 (c+ partial)
RH:5 (e+ weak, partial)
RH:–19 (hrS–)
RH:–31 (hrB–)
RH:–61 (CEVF–)

c and e

anti-c and -e

not known

not found

RHCE*01.07.02
RHCE*ce.07.02
RHCE*ceMO.02

c.667G>T

5

p.Val223Phe

RHCE*ceMO.02 without 16Cys, less often seen than ceMO.01
but also often with RHD*DAU0

Asian: unknown
Black: rare
Caucasian: none

rs147357308

RH:4 (c+ partial)
RH:5 (e+ weak, partial)
RH:–19 (hrS–)
RH:–31 (hrB–)
RH:–61 (CEVF–)

not found

RHCE*01.08
RHCE*ce.08
RHCE*ceBI

c.48G>C
c.712A>G
c.818C>T
c.1132C>G

1
5
6
8

p.Trp16Cys
p.Met238Val
p.Ala273Val
p.Leu378Val

RHCE*ceBI, often linked to RHD*DOL

Asian: unknown
Black: some
Caucasian: unknown

rs586178
rs144163296
rs147094099
rs138917454

RH:5 (e+ partial, weak to neg)
RH:–18,–19 (Hr–, hrS–)
RH:49 (STEM+)

e

anti-e
anti-RH19 (-hrS)
anti-RH18 (-Hr)

not known

AF510066

RHCE*01.09
RHCE*ce.09
RHCE*ceSM

c.48G>C
c.712A>G
c.818C>T

1
5
6

p.Trp16Cys
p.Met238Val
p.Ala273Val

RHCE*ceSM

Asian: unknown
Black: some
Caucasian: unknown

rs586178
rs144163296
rs147094099

RH:5 (e+ positive to negative)
RH:–18 (Hr–), inferred
RH:–19 (hrS–)
Rh:49 (STEM+ weak)

not known

not known

not known

GU474431

RHCE*01.10.01.01
RHCE*ce.10.01.01
RHCE*ceSL.01.01

c.48G>C
c.365C>T

1
3

p.Trp16Cys
p.Ser122Leu

Reported as RHCE*ceSL

Asian: none
Black: none
Caucasian: rare

rs586178
rs201407774

RH:5 (e+ weak)
Some monoclonal anti-D cross-react

not known

not known

weak reactivity with some anti-D monoclonal

not found

RHCE*01.10.01.02
RHCE*ce.10.01.02
RHCE*ceSL.01.02

c.48G>C
c.105C>T
c.365C>T

1
2
3

p.Trp16Cys
p.Asp35=
p.Ser122Leu

Reported as RHCE*ceSL

Asian: none
Black: none
Caucasian: rare

rs586178
rs142971926
rs201407774

RH:5 (e+ weak)
Some monoclonal anti-D cross-react

not known

not known

weak reactivity with some anti-D monoclonal

not found

RHCE*01.10.02
RHCE*ce.10.02

c.365C>T

3

p.Ser122Leu

RHCE*ceSL.02

Asian: unknown
Black: unknown
Caucasian: rare

rs201407774

RH:5 (e+ weak)
Some monoclonal anti-D cross-react

not known

not known

Few monoclonal anti-D weakly cross-react

AM072960

RHCE*01.11
RHCE*ce.11
RHCE*ceRT

c.461G>C

3

p.Arg154Thr

RHCE*ceRT

Asian: rare
Black: unknown
Caucasian: rare

rs747471048

RH:5 (e+ weak)
Some monoclonal anti-D cross-react

not known

not known

Some monoclonal anti-D weakly cross-react

AM072961

RHCE*01.12
RHCE*ce.12
RHCE*ceRA

c.48G>C
c.538G>C

1
4

p.Trp16Cys
p.Gly180Arg

RHCE*ceRA

Asian: rare
Black: unknown
Caucasian: unknown

rs586178
not found

RH:5 (e+ weak)

not known

not known

not known

not found

RHCE*01.13
RHCE*ce.13
RHCE*ceBP

c.687_689delAAG

5

p.Arg229del

RHCE*ceBP

Asian: unknown
Black: rare
Caucasian: unknown

rs1437180947

RH:5 (e+ very weak)
RH:58 (CELO+ weak)

not known

not known

not known

not found

RHCE*01.14
RHCE*ce.14
RHCE*ceBE

c.662C>G

5

p.Pro221Arg

RHCE*ceBE

Asian: rare
Black: unknown
Caucasian: unknown

rs141398055

RH:4 (c+ weak)
RH:5 (e+ weak)
RH:36 (Be^a+)

not known

not known

not known

AM295500

RHCE*01.15
RHCE*ce.15
RHCE*ceLOCR

c.286G>A

2

p.Gly96Ser

RHCE*ceLOCR

Asian: unknown
Black: unknown
Caucasian: rare

rs144348222

RH:4 (c+ weak)
RH:5 (e+ weak)
RH:55 (LOCR+)
RH:–26

not known

not known

not known

not found

RHCE*01.16
RHCE*ce.16

c.48G>C
c.1170C>T
c.1193T>A

1
9

p.Trp16Cys
p.Leu390=
p.Val398Glu

RHD*pseudogene

rs586178
rs630931
rs630612

RH:5 (e+ weak)

KU234778

RHCE*01.17
RHCE*ce.17

c.505C>A
c.509G>T
c.514T>A

4

p.Leu169Met
p.Arg170Met
p.Phe172Ile

rs1020280601
rs987753117
rs1053349

Some monoclonal anti-D crossreact

MW924818

RHCE*01.18
RHCE*ce.18

c.939G>A

6

p.Pro313=

rs754703211

RH:5 (e+ weak)

not found

RHCE*01.20.01
RHCE*ce.20.01
RHCE*ceVS.01

c.733C>G

5

p.Leu245Val

Often linked to conventional RHD*01

Asian: none
Black: common
Caucasian: none

rs1053361

RH:4 (c+ partial)
RH:5 (e+ partial)
RH:10,20 (V+VS+)
RH:31 (hrB+ very weak to neg)

anti-e (auto)??

Numerous patients have received e+ blood without adverse effects

not found

RHCE*01.20.02.01
RHCE*ce.20.02.01
RHCE*ceVS.02.01

c.48G>C
c.733C>G

1
5

p.Trp16Cys
p.Leu245Val

Often linked to RHD*DIIIa or to RHD*weak partial D 4.0

Asian: none
Black: common
Caucasian: none

rs586178
rs1053361

RH:4 (c+ partial)
RH:5 (e+ partial)
RH:10,20 (V+VS+)
RH:–31 (hrB–)

anti-e (auto)??

Numerous patients have received e+ blood without adverse effects

not found

RHCE*01.20.02.02
RHCE*ce.20.02.02
RHCE*ceVS.02.02

c.48G>C
c.105C>T
c.733C>G

1
2
5

p.Trp16Cys
p.Asp35=
p.Leu245Val

rs586178
rs142971926
rs1053361

Inferred as
RHCE*01.20.02.01

not found

RHCE*01.20.03
RHCE*ce.20.03
RHCE*ceVS.03
RHCE*ceS

c.48G>C
c.733C>G
c.1006G>T

1
5
7

p.Trp16Cys
p.Leu245Val
p.Gly336Cys

RHCE*ceS, often linked to RHD*DIIIa, to hybrid RHD*DIIIa-CEVS(4-7)-D as part of r’^S type 1 or to RHD*D-CEVS(4-7)-D as part of r’^S type 2 haplotype

Asian: none
Black: common
Caucasian: none

rs586178
rs1053361
rs116261244

RH:4 (c+ partial)
RH:5 (e+ partial)
RH:–10,20 (V–VS+)
RH:–31 (hrB–)

e and c

anti-e or anti-c

not known
when linked with hybrid D-CE-D, the RH2 (C) antigen is partial

not found

RHCE*01.20.04.01
RHCE*ce.20.04.01
RHCE*ceVS.04.01
RHCE*ceTI type 2

c.48G>C
c.733C>G
c.1025C>T

1
5
7

p.Trp16Cys
p.Leu245Val
p.Thr342Ile

RHCE*ceTI type 2

Asian: none
Black: some
Caucasian: none

rs586178
rs1053361
rs1053374

RH:5 (e+ partial)
RH:10,20 (V+VS+)
Probable RH:–31 (hrB–)

not known

not known

not known

KY652757

RHCE*01.20.04.02
RHCE*ce.20.04.02
RHCE*ceVS.04.02

c.48G>C
c.105C>T
c.733C>G
c.744T>C
c.1025C>T

1

5

7

p.Trp16Cys
p.Asp35=
p.Leu245Val
p.Ser248=
p.Thr342Ile

Reported as RHCE*ceTI type 2 as above but noting the silent changes

rs586178
rs142971926
rs1053361
rs149352457
rs1053374

Inferred as
RHCE*01.20.04.01
RHCE*ceTI type 2

not found

RHCE*01.20.05
RHCE*ce.20.05
RHCE*ceVS.05

c.733C>G
c.1006G>T

5
7

p.Leu245Val
p.Gly336Cys

Asian: none
Black: rare
Caucasian: none

rs1053361
rs116261244

RH:5 (e+ partial)
RH:–10,20 (V–VS+)
RH:–31 (hr^B–)

not known

not known

not known

not found

RHCE*01.20.06
RHCE*ce.20.06
RHCE*ceVS.06
RHCE*ceCF

c.48G>C
c.697C>G
c.733C>G

1
5

p.Trp16Cys
p.Gln233Glu
p.Leu245Val

RHCE*ceCF

Asian: none
Black: some
Caucasian: none

rs586178
rs142246017
rs1053361

RH:4 (c+ partial)
RH:5 (e+ partial, positive to negative)
RH:20 (VS+)
RH:–19,–31 (hr^S–, hr^B–)
RH:43 (Crawford+)
RH:–58 (CELO–)
Some monoclonal anti-D cross-react

c and e

anti-c anti-e

Anti-CELO DAT+, no HDFN

Moderate to strongly reactive with some monoclonal anti-D

DQ178642

RHCE*01.20.06.02
RHCE*ce.20.06.02
RHCE*ceVS.06.02

c.697C>G
c.733C>G

5

p.Gln233Glu
p.Leu245Val

rs142246017
rs1053361

Some monoclonal anti-D cross-react

MW924817

RHCE*01.20.07
RHCE*ce.20.07
RHCE*ceVS.07

c.340C>T
c.733C>G

3
5

p.Arg114Trp
p.Leu245Val

RHCE*ceJAL

Asian: none
Black: some
Caucasian: none

rs148487630
rs1053361

RH:4 (c+ partial, weak to neg)
RH:5 (e+ partial, weak to neg)
RH:10 (V+ weak to neg)
RH:19 (hrS+ weak to neg)
RH:20 (VS+ weak to neg)
RH:31 (hrB+ weak to neg)
RH:48 (JAL+)
RH:–57 (CEST–)

c and e

anti-e anti-c

anti-RH4 (c) possibly involved in transfusion reaction

AF510067

RHCE*01.20.08
RHCE*ce.20.08
RHCE*ceVS.08

c.48G>C
c.733C>G
c.748G>A

1
5

p.Trp16Cys
p.Leu245Val
p.Val250Met

Asian: none
Black: rare
Caucasian: none

rs586178
rs1053361
not found

RH:5 (e+ weak)
RH:10,20 (V+VS+)
Probable RH:–31 (hrB–)

AF510068

RHCE*01.20.09
RHCE*ce.20.09
RHCE*ceVS.09

c.48G>C
c.733C>G
c.941T>C

1
5
7

p.Trp16Cys
p.Leu245Val
p.Val314Ala

Asian: none
Black: rare
Caucasian: none

rs586178
rs1053361
rs79321360

RH:5 (e + weak)
RH:10,20 (V+VS+)
RH:31 (hrB+ weak)

e

anti-e

not known

KX279465

RHCE*01.20.10
RHCE*ce.20.10
RHCE*ceVS.10

c.48G>C
c.712A>G
c.733C>G

1
5

p.Trp16Cys
p.Met238Val
p.Leu245Val

rs586178
rs144163296
rs1053361

Probable RH:4 (c+ partial)
Probable RH:5 (e+ partial)

made anti-hrB

KY369955

RHCE*01.20.11
RHCE*ce.20.11
RHCE*ceVS.11

c.48G>C
RHD exons 2-3
c.186G>T
c.410C>T
c.455A>C
c.733C>G
c.1006G>T

1

2
3

5
7

p.Trp16Cys

p.Leu62Phe
p.ALa137Val
p.Asn152Thr
p.Leu245Val
p.Gly336Cys

RHCE*ceS-DIIIa(2-3)-ce

rs586178

rs199509194
rs113982491
rs17418085
rs1053361
rs116261244

KY926711

RHCE*01.20.12
RHCE*ce.20.12
RHCE*ceVS.12

c.48G>C
c.462G>T
c.733C>G
c.1006G>T

1
3
5
7

p.Trp16Cys
p.Arg154Ser
p.Leu245Val
p.Gly336Cys

RHCE*ceS+462T

rs586178
not found
rs1053361
rs116261244

Some monoclonal anti-D cross-react

Reactive with anti-D (Immucor gammaclone)

MW349827

RHCE*01.20.13
RHCE*ce.20.13
RHCE*ceVS.13

c.48G>C
c.106G>A
c.733C>G

1

5

p.Trp16Cys
p.Ala36Thr
p.Leu245Val

RHD*weak D type 4.3 (RHD*09.05)

rs586178
rs145034271
rs1053361

RH:5 (e+)
RH:9 (Cx+)
RH:20 (VS+)

not found

RHCE*01.21.01
RHCE*ce.21.01

c.341G>A

3

p.Arg114Gln

Asian: one
Black: unknown
Caucasian: one

rs1238030431

RH:5 (e+ weak)
RH:48 (JAL+)

AJ548432

RHCE*01.21.02
RHCE*ce.21.02

c.48G>C
c.187G>C
c.341G>A

1
2
3

p.Trp16Cys
p.Gly63Arg
p.Arg114Gln

rs586178
not found
rs1238030431

RH:5 (e+ weak)
RH:48 (JAL+)

AM295498

RHCE*01.22.01
RHCE*ce.22.01

c.667G>T
c.697C>G
c.712A>G
c.733C>G
c.744T>C
c.787A>G
c.800T>A

5

p.Val223Phe
p.Gln233Glu
p.Met238Val
p.Leu245Val
p.Ser248=
p.Arg263Gly
p.Met267Lys

DHAR, RHCE*ceHAR

Asian: none
Black: none
Caucasian: some

rs147357308
rs142246017
rs144163296
rs1053361
rs149352457
rs1132763
rs1132764

RH:5 (e+ weak)
RH:33 (DHAR+)
RH:50 (FPPT+)
Some monoclonal anti-D cross-react

strongly D+ with some monoclonal anti-D

not found

RHCE*01.22.02
RHCE*ce.22.02

c.48G>C
c.667G>T
c.697C>G
c.712A>G
c.733C>G
c.744T>C
c.787A>G
c.800T>A

1
5

p.Trp16Cys
p.Val223Phe
p.Gln233Glu
p.Met238Val
p.Leu245Val
p.Ser248=
p.Arg263Gly
p.Met267Lys

RHCE*ceHAR.02

rs586178
rs147357308
rs142246017
rs144163296
rs1053361
rs149352457
rs1132763
rs1132764

Inferred as
RHCE*01.22.01
RHCE*ceHAR.01

not found

RHCE*01.23
RHCE*ce.23

c.649T>C

5

p.Trp217Arg

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:5 (e+ weak)

FJ486162

RHCE*01.24
RHCE*ce.24

c.512A>G

4

p.His171Arg

Asian: unknown
Black: unknown
Caucasian: rare

rs781037009

RH:5 (e+ weak)

AM182448

RHCE*01.25
RHCE*ce.25

c.730G>A

5

p.Ala244Thr

Asian: unknown
Black: unknown
Caucasian: rare

rs1307519228

RH:5 (e+ weak)

AM260938

RHCE*01.26
RHCE*ce.26

c.872C>T

6

p.Pro291Leu

Asian: unknown
Black: unknown
Caucasian: rare

rs374399829

RH:5 (e+ weak)

AM183927

RHCE*01.27
RHCE*ce.27

c.1154G>C

9

p.Gly385Ala

Asian: unknown
Black: unknown
Caucasian: rare

rs1412021250

RH:5 (e+ weak)

AM295499

RHCE*01.28
RHCE*ce.28

c.1254A>C

10

p.Ter418Tyr

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:4 (c+ weak)

AM295503

RHCE*01.29
RHCE*ce.29

RHD exons 4-9

4-9

RHCE*ceBOL
haplotype (Dc– Bol)

Asian: unknown
Black: unknown
Caucasian: one

NA

RH:4,–5 (c+e–)

not found

RHCE*01.30
RHCE*ce.30

c.526G>A

4

p.Ala176Thr

Asian: unknown
Black: rare
Caucasian: unknown

rs753965768

RH:5 (e+ weak)

not found

RHCE*01.31
RHCE*ce.31

c.695T>C

5

p.Ile232Thr

Asian: unknown
Black: rare
Caucasian: unknown

not found

RH:5 (e+ weak)

not found

RHCE*01.32
RHCE*ce.32

c.827C>A

6

p.Ala276Glu

Asian: unknown
Black: rare
Caucasian: unknown

not found

not found

RHCE*01.33
RHCE*ce.33

c.506T>C

4

p.Leu169Pro

rs1310627729

RH:5 (e+ partial, weak to neg)
RH:–31 (hrB–)

KX714949

RHCE*01.34
RHCE*ce.34

RHD exons 4-7

4-7

Haplotype Dc–

NA

RH:4 (c+ partial)
RH:–5 (e–)

Made antibody to high-frequency antigen

KY652756

RHCE*01.35
RHCE*ce.35

c.202A>G

2

p.Asn68Asp

(ce in trans)

rs772058645

.

KP136911

RHCE*01.36
RHCE*ce.36

c.307C>T

2

p.Pro103Ser

rs676785

RH:2 (C+ partial, robust C+ expression)
RH:–4 (c–)

KP136912

RHCE*01.37
RHCE*ce.37

c.697C>G
c.712A>G
c.733C>G
c.744T>C

5

p.Gln233Glu
p.Met238Val
p.Leu245Val
p.Ser248=

(ce in trans)

rs142246017
rs144163296
rs1053361
rs149352457

.

Reported as weakly reactive with anti-D in absence of RHD

KP136915

RHCE*01.38
RHCE*ce.38

c.1-10C>T

5’UTR

promoter region

rs369957834

RH:5 (e+ weak)

FM866412

RHCE*01.39
RHCE*ce.39

c.308C>T

2

p.Pro103Leu

rs747882675

RH:2 (C+ weak)
RH:–4 (c–)

KU319432

RHCE*01.40
RHCE*ce.40

c.340C>T

3

p.Arg114Trp

rs148487630

RH:4 (c+ weak)

KR060081

RHCE*01.41
RHCE*ce.41

c.114A>C

2

p.Leu38Phe

not found

RH:–8 (Cw–)
RH:9 (Cx+ weak)
Rh:–51 (MAR–)
RH:–62 (PARG–)

weakly reactive with three examples of anti-RH9 (C^x)

not found

RHCE*01.42
RHCE*ce.42

c.508A>G

4

p.Arg170Gly

RHCE*ceRG

not found

c+e+
Some monoclonal anti-D crossreact

reactive with anti-D (MS-26, HM10, ESD1, HM16) in the absence of RHD

KX236061

RHCE*01.43
RHCE*ce.43

c.499A>G

4

p.Met167Val

rs779408591

RH:3 (E+ weak to neg)

not found

RHCE*01.44
RHCE*ce.44

RHD exons 5-6

5-6

NA

RH:4 (c+ partial, weak)
RH:5 (e+ partial, weak)

MW349828

RHCE*01N.01
RHCE*ceN.01

c.80_84delTCTTC

1

p.Tyr29Phefs*5

not found

RH:–4,–5,–17 (c–e–)

first found in a sample with anti-Rh17 and anti-Rh29

anti-RH17: no to severe HDFN

not found

RHCE*01N.02
RHCE*ceN.02

c.963delG

7

p.Iso322Phefs*37

not found

RH:–4,–5,–17 (c–e–)

anti-Rh17, anti-Rh29

anti-RH17: no to severe HDFN

not found

RHCE*01N.03
RHCE*ceN.03

c.634+1G>T

Intron 4

Splice site

not found

RH:–4,–5,–17 (c–e–)

anti-Rh17, anti-Rh29

anti-RH17: no to severe HDFN

not found

RHCE*01N.04
RHCE*ceN.04

c.676delG

5

p.Ala226Leufs*3

not found

RH:–4,–5,–17 (c–e–), inferred
(ce in trans)

KY652755

RHCE*01N.05
RHCE*ceN.05

c.335+3A>T

Intron 2

Splice site

not found

RH:–5 (e–)
(cE in trans)

KX714951

RHCE*01N.06
RHCE*ceN.06

c.679_683delCTGCT

5

p.Leu227Glufs*89

not found

RH:–4,–5,–17 (c–e–)

not found

RHCE*01N.07
RHCE*ceN.07

c.1074-2A>G

Intron 7

Splice site

not found

RH:–4 (c–)
(ce or Ce in trans)

not found

RHCE*01N.08
RHCE*ceN.08

c.801+1G>A

5

Splice site

not found

RH:–4,–5,–17 (c–e–)

KY229720

RHCE*01N.09
RHCE*ceN.09

c.1044_1050dupGCTTCAT

7

p.Thr351Alafs*52

not found

RH:–4,–5,–17 (c–e–)

Made anti-RH29

not found

RHCE*01N.10
RHCE*ceN.10

c.807T>A

6

p.Tyr269Ter

rs780267740

RH:–4,–5 (c–e–)

possible trace expression of RhCE antigens

not found

RHCE*01N.11
RHCE*ceN.11

c.1154-1G>A

intron 8

Splice site

not found

RH:–4 (c–)
(Ce in trans)

MT374825

RHCE*01N.12
RHCE*ceN.12

c.48G>C
c.366delG

1
3

p.Trp16Cys
p.Val123Cysfs*1

not found

RH:-4 (c–)
(Ce in trans)

MW773845

RHCE*01N.13
RHCE*ceN.13

c.486+1G>A

Intron 3

Splice site

provisional (partially sequenced Exons 1-7)

not found

RH:–4 (c–)
(Ce in trans)

not found

RHCE*02 or
RHCE*Ce
(RHCE*C or RHCE*e
if partly characterized)

Reference nucleotides
c.48G>C
c.150C>T
c.178C>A
c.201A>G
c.203A>G
c.307C>T
c.676G

1
2




5

p.Trp16Cys
p.Val50=
p.Leu60Ile
p.Ser67=
p.Asn68Ser
p.Pro103Ser
p.Ala226

rs586178
rs200955066
rs181860403
rs1053343
rs1053344
rs676785
rs609320

RH:2 or C
RH:5 or e
RH:7 or Ce

BC075081

RHCE*02.01
RHCE*Ce.01

c.340C>T

3

p.Arg114Trp

RHCE*CeMA
RHCE*CeJAL

Asian: unknown
Black: unknown
Caucasian: rare

rs148487630

RH:2 (C+ weak to neg)
RH:5 (e+ weak)
RH:48 (JAL+)

AJ548431
AM183925

RHCE*02.02
RHCE*Ce.02

c.667G>T
c.697C>G
c.712A>G

5

p.Val223Phe
p.Gln233Glu
p.Met238Val

RHCE*CeFV

Asian: unknown
Black: unknown
Caucasian: rare

rs147357308
rs142246017
rs144163296

RH:2 (C+)
RH:5 (e+)

AJ867777

RHCE*02.03
RHCE*Ce.03

c.365C>T

3

p.Ser122Leu

RHCE*CeJAHK
(called CeSI in GenBank)

Asian: unknown
Black: unknown
Caucasian: rare

rs201407774

RH:2 (C+ weak to neg)
RH:5 (e+ weak)
RH:53 (JAHK+)

AM999773

RHCE*02.04
RHCE*Ce.04

c.667G>T
c.697C>G
c.712A>G
c.733C>G
c.744T>C
c.787A>G
c.800T>A

5

p.Val223Phe
p.Gln233Glu
p.Mer238Val
p.Leu245Val
p.Ser248=
p.Arg263Gly
p.Met267Lys

RHCE*CeVA

Asian: unknown
Black: unknown
Caucasian: rare

rs147357308
rs142246017
rs144163296
rs1053361
rs149352457
rs1132763
rs1132764

RH:2 (C+ partial, weak to neg)

not found

RHCE*02.04.01
RHCE*Ce.04.01

c.667G>T
c.697C>G
c.712A>G
c.733C>G
c.744T>C
c.787A>G

5

p.Val223Phe
p.Gln233Glu
p.Mer238Val
p.Leu245Val
p.Ser248=
p.Arg263Gly

rs147357308
rs142246017
rs144163296
rs1053361
rs149352457
rs1132763

RH:2 (C+ weak)
RH:5 (e+ weak)

AM999774

RHCE*02.05
RHCE*Ce.05

c.501G>A

4

p.Met167Ile

RHCE*CePARG

not found

RH:60 (PARG+)

not found

RHCE*02.08.01
RHCE*Ce.08.01

c.122A>G

1

p.Gln41Arg

RHCE*CeCW

Asian: unknown
Black: unknown
Caucasian: some

rs138268848

RH:2 (C+ partial)
RH:5 (e+ partial)
RH:8 (C^w+)
RH:–51 (MAR–)

anti-RH51 like (anti-MAR like)

Anti-RH2 (-C), anti-RH7 (-Ce or -rhi)

anti-RH8 (anti-C^w): no to severe HDFN

not found

RHCE*02.08.02
RHCE*Ce.08.02

c.122A>G
RHD exons 6-10

1
6-10

p.Gln41Arg

RHCE*CeNR

Asian: unknown
Black: one
Caucasian: unknown

rs138268848

RH:8 (C^w+)
RH:–56 (CENR–)

not found

RHCE*02.09
RHCE*Ce.09

c.106G>A

1

p.Ala36Thr

RHCE*CeCX

Asian: unknown
Black: unknown
Caucasian: uncommon

rs145034271

RH:2 (C+ partial)
RH:9 (C^x+)
RH:–51 (MAR–)

anti-RH51 like (anti-MAR like)

Anti-RH2 (-C), anti-RH7 (-Ce or -rhi)

anti-RH9 (anti-C^x): no to severe HDFN

not found

RHCE*02.10.01
RHCE*Ce.10.01

c.505C>A
c.509G>T
c.514T>A
c.544A>T
c.577A>G
c.594T>A
c.602G>C

4

p.Leu169Met
p.Arg170Met
p.Phe172Ile
p.Thr182Ser
p.Lys193Glu
p.Asn198Lys
p.Arg201Thr

RHCE*CeRN

Asian: none
Black: some
Caucasian: none

rs1132761
rs1132762
rs1053349
rs1053350
rs1384157219
rs1053354
rs141398055

RH:1 (D+) in the absence of conventional D
RH:2 (C+ partial, weak to neg)
RH:5 (e+ partial, weak)
RH:32
RH:54 (DAK+)
RH:–46 (Sec–)

C

Anti-RH2 (anti-C), anti-RH46 (anti-Sec)

Anti-RH46 (anti-Sec) and anti-RH2 (anti-C) are clinically significant.
No to severe HDFN

not found

RHCE*02.10.02
RHCE*Ce.10.02

(allele existence?)

c.455C>A
c.505C>A
c.509G>T
c.514T>A
c.544A>T
c.577A>G
c.594T>A
c.602G>C

3
4

p.Thr152Asn
p.Leu169Met
p.Arg170Met
p.Phe172Ile
p.Thr182Ser
p.Lys193Glu
p.Asn198Lys
p.Arg201Thr

RHCE*CeRN.02
exists?

Asian: none
Black: some
Caucasian: none

rs35109888
rs1132761
rs1132762
rs1053349
rs1053350
rs1384157219
rs1053354
rs141398055

RH:2 (C+ partial, weak to neg)
RH:5 (e+ partial, weak)
RH:32
RH:54 (DAK+)
RH:–46 (Sec–)

C

Anti-RH2 (-C), anti-RH46 (-Sec)

Anti-RH46 (-Sec) and anti-RH2 (-C) are clinically significant.
No to severe HDFN

not found

RHCE*02.11
RHCE*Ce.11

c.286G>A

2

p.Gly96Ser

Asian: unknown
Black: unknown
Caucasian: rare

rs144348222

RH:2 (C+ weak)
RH:5 (e+)
RH:55 (LOCR+)

AM295502

RHCE*02.12
RHCE*Ce.12

c.344T>G

3

p.Leu115Arg

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:2 (C+ weak)

AJ867774

RHCE*02.13
RHCE*Ce.13

c.364T>C

3

p.Ser122Pro

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:5 (e+ weak)

FJ486157

RHCE*02.14
RHCE*Ce.14

c.497A>T

4

p.His166Leu

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:2 (C+ weak)

FJ486159

RHCE*02.15
RHCE*Ce.15

c.689G>C

5

p.Ser230Thr

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:5 (e+ weak)

AM182449

RHCE*02.16
RHCE*Ce.16

c.728A>G

5

p.Tyr243Cys

Asian: unknown
Black: unknown
Caucasian: rare

rs555090649

RH:2 (C+ weak)
RH:5 (e+ weak)

FM165579

RHCE*02.17
RHCE*Ce.17

c.800T>A

5

p.Met267Lys

Asian: unknown
Black: unknown
Caucasian: rare

rs1132764

RH:5 (e+ weak)

FJ486164

RHCE*02.18
RHCE*Ce.18

c.890T>C

6

p.Leu297Pro

Asian: unknown
Black: unknown
Caucasian:rare

rs763017817

RH:2 (C+ weak)
RH:5 (e+ weak)

AM295501

RHCE*02.19
RHCE*Ce.19

c.464T>G
c.1118C>T

3
8

p.Met155Arg
p.Ala373Val

Asian: unknown
Black: unknown
Caucasian: rare

not found
not found

RH:5 (e+ weak)

AM295506

RHCE*02.20
RHCE*Ce.20

c.79_81delCTC

1

p.Leu27del

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:2 (C+ weak)
RH:5 (e+ weak)

AM410878

RHCE*02.21
RHCE*Ce.21

c.527C>T

4

p.Ala176Val

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:2 (C+ weak)

KM975479

RHCE*02.22
RHCE*Ce.22

c.667G>T

5

p.Val223Phe

Asian: unknown
Black: unknown
Caucasian: rare

rs147357308

RH:2 (C+ weak)
RH:5 (e+ partial, weak)

not found

RHCE*02.23
RHCE*Ce.23

c.941T>C

7

p.Val314Ala

Asian: unknown
Black: unknown
Caucasian: rare

rs79321360

RH:2 (C+ weak)

not found

RHCE*02.24
RHCE*Ce.24

c.1007G>A

7

p.Gly336Asp

Asian: unknown
Black: unknown
Caucasian: rare

rs760319839

RH:2 (C+ weak)
RH:5 (e+ weak)

not found

RHCE*02.25
RHCE*Ce.25

c.1007G>T

7

p.Gly336Val

Asian: unknown
Black: unknown
Caucasian: rare

rs760319839

RH:2 (C+ weak)

not found

RHCE*02.26
RHCE*Ce.26

c.460A>G

3

p.Arg154Gly

rs755299894

RH:2 (C+ weak)
RH:5 (e+ weak)

KU744002

RHCE*02.27
RHCE*Ce.27

c.375C>G

3

p.Ile125Met

Asian: rare
Black: unknown
Caucasian: unknown

rs143715642

RH:2 (C+ weak)
RH:5 (e+ weak)

KM078027

RHCE*02.28
RHCE*Ce.28

c.919G>A

6

p.Gly307Arg

rs200950594

RH:2,5 (C+e+)
RH:9 (C^x+)

Made antibody to high in Rh

Surprisingly RH:9 (C^x+) in the absence of c.106A

KY190222

RHCE*02.29
RHCE*Ce.29

c.674C>G

5

p.Ser225Cys

rs200087488

RH:2 (C+)
RH:3 (E+ pos to neg)
RH:5 (e+)

RH3 (E): 0 to 4+ depending on reagent, in the absence of c.676C 

KY190223

RHCE*02.30
RHCE*Ce.30

c.733C>G

5

p.Leu245Val

rs1053361

RH:2,5 (C+e+)
RH:10,20 (V+VS+)

KP136918

RHCE*02.31
RHCE*Ce.31

c.487-5T>G

Intron 3

Splice site

rs776819527

RH:2 (C+ weak)
RH:5 (e+ weak)

FM866415

RHCE*02.32
RHCE*Ce.32

c.1228-2A>G

Intron 9

Splice site

not found

RH:2 (C+ weak)

FM866417

RHCE*02.33
RHCE*Ce.33

c.98A>C

1

p.His33Pro

not found

RH:2 (C+ weak)

not found

RHCE*02.34
RHCE*Ce.34

c.473G>A

3

p.Ser158Asn

rs758173067

RH:2 (C+ weak)
RH:5 (e+ weak)

not found

RHCE*02.35
RHCE*Ce.35

c.491A>G

4

p.Asp164Gly

rs548044758

RH:2 (C+ weak)

not found

RHCE*02.36
RHCE*Ce.36

c.494A>C

4

p.Tyr165Ser

rs746303049

RH:2 (C+ weak)

not found

RHCE*02.37
RHCE*Ce.37

Lacking the 109bp insert

intron 2

RH:2 (C+)

not found

RHCE*02.38
RHCE*Ce.38

c.939G>A

6

p.Pro313=

rs754703211

RH:2 (C+ weak)
RH:5 (e+ weak)

not found

RHCE*02.39
RHCE*Ce.39

c.1154G>T 

9

p.Gly385Val

rs1412021250

RH:2 (C+ very weak)

MW427217

RHCE*02.40
RHCE*Ce.40

c.712A>G
c.733C>G
c.787A>G
c.800T>A
c.916A>G

5



6

p.Met238Val
p.Leu245Val
p.Arg263Gly
p.Met267Lys
p.Ile306Val

RHCE*CeAR

rs586178
rs144163296
rs1053361
rs1132763
rs1132764
rs1132765

RH:2 (C+ weak, mixed field)
RH:–10 (V–)

not found

RHCE*02.41
RHCE*Ce.41
(provisional)

c.1151C>T

8

p.Thr384Ile

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:2 (C+ very weak)

OK169896

RHCE*02.42
RHCE*Ce.42
(provisional)

c.209G>A

2

p.Arg70Gln

rs371998475

RH:2 (C+)

MW355847

RHCE*02.43
RHCE*Ce.43
(provisional)

c.710C>A

5

p.Ala237Asp

RHD

Japanese

rs540803248

RH:2 (C+ weak)
RH:5 (e‒; Adsorption-elution not performed)

ON542593

RHCE*02N.01
RHCE*CeN.01

c.966_968delinsC

7

p.His323Profs*77

not found

RH:–2,–5,–17 (C–e–)

Anti-Rh17?

not found

RHCE*02N.02
RHCE*CeN.02

c.659G>A

5

p.Trp220Ter

not found

RH:–2 (C–)
RH: –5 (e–), inferred
RH:–17, inferred

KX714950

RHCE*02N.03
RHCE*CeN.03

c.486+1G>A

Intron 3

Splice site

rs753832633

RH:–2 (C–)
(ce in trans)

KP334130

RHCE*02N.04
RHCE*CeN.04

c.93insT

1

p.Thr32Tyrfs*3

Reported as c.93_94insT

not found

RH:–2,–5 (C–e–)

not found

RHCE*02N.05
RHCE*CeN.05

c.377C>G

3

p.Ser126Ter

not found

RH:–2,–5 (C–e–)
RH:–17, inferred

KP136914

RHCE*02N.06
RHCE*CeN.06

c.148+5G>A

Intron 1

Splice site

rs756955857

RH:–2,–5,–17 (C–e–)

not found

RHCE*02N.07
RHCE*CeN.07

RHD exons 3-8

3-8

NA

RH:–2,–5,–17 (C–e–)

not found

RHCE*02N.08
RHCE*CeN.08

RHD exons 3-9

3-9

NA

RH:–2,–5,–17 (C–e–)

not found

RHCE*02N.09
RHCE*CeN.09

c.938delC

6

p.Pro313Argfs*46

not found

RH:–2,–5,–17 (C–e–)

Anti-RH17

Hemolytic transfusion reaction

not found

RHCE*02N.10
RHCE*CeN.10

c.482insT

3

p.Asn162Glnfs*37

not found

MK090017

RHCE*02N.11
RHCE*CeN.11

c.148G>A

1

p.Val50Ile

not found

MT210599

RHCE*02N.12
RHCE*CeN.12

c.1059delG

7

p.Trp353Ter

not found

RH:–2 (C–)
RH:–5 (e–), inferred
RH:–17, inferred

MW355846

RHCE*02N.13
RHCE*CeN.13

c.635-9G>A

Intron 4

Splice site

rs767724106

RH:–2 (C–)
RH:–5 (e–), inferred

MZ351768

RHCE*02N.14
RHCE*CeN.14

c.569_572dupCTCT

4

p.Pro192Serfs*8

Asian: rare
Black: none
Caucasian: none

not found

RH:–2,–5,–17 (C–e–)

probably anti-Rh17

MK388216

RHCE*02N.15
RHCE*CeN.15
(provisional)

c.577A>T

4

p.Lys193Ter

Asian: unknown
Black: unknown
Caucasian: rare

rs1384157219

RH:–2,–5,–17 (C–e–)

OK169897

RHCE*02N.16
RHCE*CeN.16
(provisional)

c.855delT

6

p.His286Thrfs*2

not found

RH:–2 (C–)
RH:–5 (e–), inferred
RH:–17, inferred

OK216201

RHCE*02N.17
RHCE*CeN.17
(provisional)

c.148+5G>T

Intron 1

Splice site

rs756955857

RH:–2 (C–), inferred
RH:–5 (e–)
RH:–17 (Hr₀–), inferred

RHCE*02N.18
RHCE*CeN.18
(provisional)

c.939+1G>A

Intron 6

Splice site

rs751221592

RH:–2 (C–)
RH:–5 (e–)
RH:–17 (Hr₀–), inferred

RHCE*03 or
RHCE*cE
(RHCE*c or RHCE*E
if partly characterized)

Reference nucleotides
c.307C
c.676G>C

2
5

p.Pro103
p.Ala226Pro

RH:4 or c
RH:3 or E
RH:27 or cE

RHCE*03.01
RHCE*cE.01

c.500T>A

4

p.Met167Lys

RHCE*cEEW

Asian: rare
Black: unknown
Caucasian: rare

rs140421430

RH:3 (E+ partial, weak to neg)
RH:11 (E^w+)

E

Anti-E

E type I

not found

RHCE*03.02
RHCE*cE.02

RHD exons 1-3

1-3

RHCE*cEKK

Asian: rare
Black: unknown
Caucasian: rare

NA

RH:3 (E+ partial, weak to neg)
RH:4 (c+ weak to neg)

E type II

AB049753

RHCE*03.03
RHCE*cE.03

c.697C>G
c.712A>G

5

p.Gln233Glu
p.Met238Val

RHCE*cEFM

Asian: rare
Black: unknown
Caucasian: rare

rs142246017
rs144163296

RH:3 (E+ partial, weak to neg)

no

E type III

AB018644

RHCE*03.03.02
RHCE*cE.03.02

c.697C>G
c.712A>G
c.733C>G
c.744T>C

5

p.Gln233Glu
p.Met238Val
p.Leu245Val
p.Ser248=

rs142246017
rs144163296
rs1053361
rs149352457

RH:3 (E+ partial, weak to neg)

KY369956

RHCE*03.03.03
RHCE*cE.03.03

c.697C>G

5

p.Gln233Glu

rs142246017

RH:3 (E+ partial, weak to neg)

RH3 (E):
negative by PK7300
1+w to 4+ depending on reagent

MK934127

RHCE*03.04
RHCE*cE.04

c.602G>C

4

p.Arg201Thr

RHCE*cEIV

Asian: unknown
Black: unknown
Caucasian: rare

rs141398055

RH:3 (E+ partial, weak to neg)
RH:4 (c+ weak)

no

E type IV

FJ486161

RHCE*03.05
RHCE*cE.05

c.461G>C

3

p.Arg154Thr

RHCE*cEKH

Asian: rare
Black: unknown
Caucasian: unknown

rs747471048

RH:3 (E+ partial, weak to neg)
RH:4 (c+ weak to neg)

E

Anti-E

E type V

AB018645

RHCE*03.06
RHCE*cE.06

c.28C>T

1

p.Arg10Trp

Asian: unknown
Black: unknown
Caucasian: rare

rs749601047

RH:3 (E+ weak)
RH:4 (c+ weak)

FJ486155

RHCE*03.07
RHCE*cE.07

c.344T>C

3

p.Leu115Pro

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:3 (E+ weak)

FJ486156

RHCE*03.08
RHCE*cE.08

c.356G>A

3

p.Ser119Asn

rs777819701

RH:3 (E+ weak)

AM295505

RHCE*03.09
RHCE*cE.09

c.374T>A

3

p.Ile125Asn

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:3 (E+ weak)
RH:4 (c+ weak)

FJ486158

RHCE*03.10
RHCE*cE.10

c.506T>A

4

p.Leu169Gln

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:3 (E+ weak)

FJ486160

RHCE*03.11
RHCE*cE.11

c.908T>A

6

p.Leu303Gln

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:3 (E+ weak)
RH:4 (c+ weak)

FJ486165

RHCE*03.12
RHCE*cE.12

c.464T>G
c.477T>G

3

p.Met155Arg
p.Asn159Lys

Asian: unknown
Black: unknown
Caucasian: rare

not found
not found

RH:3 (E+ weak)

AM183926

RHCE*03.13
RHCE*cE.13

c.728A>G

5

p.Tyr243Cys

Asian: unknown
Black: unknown
Caucasian: rare

rs555090649

RH:3 (E+ weak)
RH:4 (c+ weak)

not found

RHCE*03.14
RHCE*cE.14

c.734T>C

5

p.Leu245Pro

Asian: unknown
Black: unknown
Caucasian: rare

not found

RH:3 (E+ very weak to neg)
RH:4 (c+ weak)

not found

RHCE*03.15.01
RHCE*cE.15.01

c.380C>T
c.383G>A

3

p.Ala127Val
p.Gly128Asp

RHCE*cE BA

rs1053346
rs1053347

RH:3 (E+ weak)

not found

RHCE*03.15.02
RHCE*cE.15.02

c.361A>T
c.380C>T
c.383G>A

3

p.Met121Leu
p.Ala127Val
p.Gly128Asp

RHCE*cE JU

Asian: unknown
Black: unknown
Caucasian: rare

rs1053345
rs1053346
rs1053347

RH:3 (E+ weak)

not found

RHCE*03.16
RHCE*cE.16

c.94A>G

1

p.Thr32Ala

RHCE*cE TA

rs760999674

RH:4 (c+ weak)

anti-RH4 (anti-c) clone 951 non-reactive

KP271157

RHCE*03.17
RHCE*cE.17

c.520G>A

4

p.Val174Met

rs146306079

RH:3 (E+ partial)

KY190221

RHCE*03.18
RHCE*cE.18

c.48G>C

1

p.Trp16Cys

rs586178

RH:3 (E+)
RH:4 (c+)

KY228976

RHCE*03.19
RHCE*cE.19

c.84C>A

1

p.Phe28Leu

not found

RH:3 (E+ weak to neg)
RH:4 (c+ weak to neg)

RH3 (E): 0 to 1+ depending on reagent
RH4 (c): 0 to 3+

KP136913
LN554880

RHCE*03.20
RHCE*cE.20

c.149-1G>A

Intron 1

Splice site

not found

RH:3 (E+ weak to neg)
RH:4 (c+ weak)

FM866414

RHCE*03.21
RHCE*cE.21

c.527C>T

4

p.Ala176Val

not found

RH:3 (E+ weak)

not found

RHCE*03.22
RHCE*cE.22

c.208C>T

2

p.Arg70Trp

rs1239729684

RH:3 (E+ weak)

not found

RHCE*03.23
RHCE*cE.23

c.774G>A
c.916A>G

5

p.Leu258=
p.Ile306Val

not found
rs1132765

RH:3 (E+ weak)

not found

RHCE*03.24
RHCE*cE.24

c.1130C>T

8

p.Ala377Val

not found

RH:3 (E+ weak)

not found

RHCE*03.25
see RHCE*03N.07

see RHCE*03N.07

see RHCE*03N.07

see RHCE*03N.07

see RHCE*03N.07

see RHCE*03N.07

RHCE*03.26
RHCE*cE.26

c.48G>C
c.307C>T

1
2

p.Trp16Cys
p.Pro103Ser

rs586178 
rs676785 

RH:2 (C+ weak to neg)
RH:3 (E+)

RH:2 (C): neg to 3+ depending on reagent

MG434498

RHCE*03.27
RHCE*cE.27

c.307C>T

2

p.Pro103Ser

rs676785

Some monoclonal anti-C cross-react

KX216810

RHCE*03.28
RHCE*cE.28

c.382G>C

3

p.Gly128Arg

not found

RH:3 (E+ weak to neg)

MW462131

RHCE*03.29
RHCE*cE.29

c.818C>A

ex6

p.Ala273Glu

not found

RH:3 (E+ very weak)
RH:4 (c+ weak to neg)

MZ351767

RHCE*03.30
RHCE*cE.30

c.336-2A>G

Intron 2

Splice site

not found

RH:3 (E+ very weak)

MZ351769

RHCE*03.31
RHCE*cE.31
RHCE*cEMI

(formerly RHCE*03N.01)

c.350_358delCCATGAGTG

3

p.Arg120_ Ser122del

RHCE*cEMI

Asian: unknown
Black: rare
Caucasian: unknown

not found

RH:3 (E+ very weak to neg)
RH:4 (c+ weak to neg)
RH:17

weak c only with Ortho (column agglutination)
weak E only with HIRO-18 anti-E

not found

RHCE*03.32
RHCE*cE.32

c.361A>T
c.380C>T
c.383G>A
c.455C>A

3

rs1053345
rs1053346
rs1053347
rs35109888

RH:3 (E+ weak to neg)

not found

RHCE*03.33
RHCE*cE.33

(provisional)

c.361A>T

3

p.Met121Leu

rs1053345

RH:3 (E+)
RH:4 (c+)

OK169895

RHCE*03N.01
RHCE*cEN.01
RHCE*ceMI

see RHCE*03.31

see RHCE*03.31

see RHCE*03.31

see RHCE*03.31

see RHCE*03.31

see RHCE*03.31

RHCE*03N.02
RHCE*cEN.02

c.907delC

6

p.Leu303Ter

Asian: unknown
Black: unknown
Hispanic: some
Caucasian: unknown

rs747976226

RH:–3,–4,–17 (E–c–)

GU563377

RHCE*03N.03
RHCE*cEN.03

c.554G>A

4

p.Trp185Ter

rs1395012563

RH:–3,–4 (E–c–)
RH:–17, inferred

not found

RHCE*03N.04
RHCE*cEN.04

c.486+5G>A

Intron 3

Splice site

not found

RH:–3,–4,–17 (E–c–)

made Anti-RH17

not found

RHCE*03N.05
RHCE*cEN.05

c.221G>A

2

p.Trp74Ter

rs1044945369

RH:–3,–4,–17 (E–c–)

not found

RHCE*03N.06
RHCE*cEN.06

c.200C>A

2

p.Ser67Ter

not found

RH:–3,–4 (E–c–)
RH:–17, inferred

MT374824

RHCE*03N.07
RHCE*cEN.07
(formerly RHCE*03.25)

c.659G>A

5

p.Trp220Ter

not found

RH:–3,–4,–17 (E–c–)

anti-RH17?

not found

RHCE*CE or
RHCE*04
(RHCE*C or RHCE*E
if partly characterized)

Reference nucleotides
c.48G>C
c.150C>T
c.178C>A
c.201A>G
c.203A>G
c.307C>T
c.676G>C

1
2




5

p.Trp16Cys
p.Val50=
p.Leu60Ile
p.Ser67=
p.Asn68Ser
p.Pro103Ser
p.Ala226Pro

RH:2 or C
RH:3 or E
RH:22 or CE

RHCE*04.01
RHCE*CE.01

c.722C>T

5

p.Thr241Ile

Asian: unknown
Black: unknown
Caucasian: one

rs751751505

RH:2 (C+ weak)
RH:3 (E+ weak to neg)

FJ486163

RHCE*04.02
RHCE*CE.02

c.380C>A

3

p.Ala127Glu

rs1053346

RH:2 (C+ weak to neg)
RH:3 (E+ weak to neg)

RH2 (C): positive only by IAT and ads/elu

MH807721